000069755 001__ 69755 000069755 005__ 20190709135618.0 000069755 0247_ $$2doi$$a10.1002/anie.201705609 000069755 0248_ $$2sideral$$a104781 000069755 037__ $$aART-2017-104781 000069755 041__ $$aeng 000069755 100__ $$aPérez-López, A.M. 000069755 245__ $$aGold-Triggered Uncaging Chemistry in Living Systems 000069755 260__ $$c2017 000069755 5060_ $$aAccess copy available to the general public$$fUnrestricted 000069755 5203_ $$aRecent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs. 000069755 536__ $$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2016-TEC-13$$9info:eu-repo/grantAgreement/EC/FP7/340163/EU/New Catalytic Reactions and Exchange Pathways: Delivering Versatile and Reliable Arylation/ARYLATOR 000069755 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000069755 590__ $$a12.102$$b2017 000069755 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b14 / 171 = 0.082$$c2017$$dQ1$$eT1 000069755 592__ $$a6.155$$b2017 000069755 593__ $$aChemistry (miscellaneous)$$c2017$$dQ1 000069755 593__ $$aCatalysis$$c2017$$dQ1 000069755 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion 000069755 700__ $$aRubio-Ruiz, B. 000069755 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, V.$$uUniversidad de Zaragoza 000069755 700__ $$aHamilton, L. 000069755 700__ $$aAdam, C. 000069755 700__ $$aBray, T.L. 000069755 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza 000069755 700__ $$aBrennan, P.M. 000069755 700__ $$aLloyd-Jones, G.C. 000069755 700__ $$aSieger, D. 000069755 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, J.$$uUniversidad de Zaragoza 000069755 700__ $$aUnciti-Broceta, A. 000069755 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química 000069755 773__ $$g56, 41 (2017), 12548-12552$$pAngew. Chem.$$tANGEWANDTE CHEMIE-INTERNATIONAL EDITION$$x1433-7851 000069755 8564_ $$s738017$$uhttps://zaguan.unizar.es/record/69755/files/texto_completo.pdf$$yVersión publicada 000069755 8564_ $$s106255$$uhttps://zaguan.unizar.es/record/69755/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000069755 909CO $$ooai:zaguan.unizar.es:69755$$particulos$$pdriver 000069755 951__ $$a2019-07-09-12:26:20 000069755 980__ $$aARTICLE