doi:10.1002/anie.201705609engPérez-López, A.M.Rubio-Ruiz, B.Sebastián, V.Hamilton, L.Adam, C.Bray, T.L.Irusta, S.Brennan, P.M.Lloyd-Jones, G.C.Sieger, D.Santamaría, J.Unciti-Broceta, A.Gold-Triggered Uncaging Chemistry in Living SystemsART-2017-104781Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.2017http://zaguan.unizar.es/record/6975510.1002/anie.201705609http://zaguan.unizar.es/record/69755oai:zaguan.unizar.es:69755info:eu-repo/grantAgreement/ES/UZ/JIUZ-2016-TEC-13info:eu-repo/grantAgreement/EC/FP7/340163/EU/New Catalytic Reactions and Exchange Pathways: Delivering Versatile and Reliable Arylation/ARYLATORANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56, 41 (2017), 12548-12552byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess