000069776 001__ 69776
000069776 005__ 20190709135556.0
000069776 0247_ $$2doi$$a10.1093/gbe/evx073
000069776 0248_ $$2sideral$$a104889
000069776 037__ $$aART-2017-104889
000069776 041__ $$aeng
000069776 100__ $$0(orcid)0000-0003-3608-4720$$aYruela, I.$$uUniversidad de Zaragoza
000069776 245__ $$aEvidence for a strong correlation between transcription factor protein disorder and organismic complexity
000069776 260__ $$c2017
000069776 5060_ $$aAccess copy available to the general public$$fUnrestricted
000069776 5203_ $$aStudies of diverse phylogenetic lineages reveal that protein disorder increases in concert with organismic complexity but that differences nevertheless exist among lineages. To gain insight into this phenomenology, we analyzed all of the transcription factor (TF) families for which sequences are known for 17 species spanning bacteria, yeast, algae, land plants, and animals and for which the number of different cell types has been reported in the primary literature. Although the fraction of disordered residues in TF sequences is often moderately or poorly correlated with organismic complexity as gauged by cell-type number (r2<0.5), an unbiased and phylogenetically broad analysis shows that organismic complexity is positively and strongly correlated with the total number of TFs, the number of their spliced variants and their total disordered residues content (r2>0.8). Furthermore, the correlation between the fraction of disordered residues and cell-type number becomes stronger when confined to the TF families participating in cell cycle, cell size, cell division, cell differentiation, or cell proliferation, and other important developmental processes. The data also indicate that evolutionarily simpler organisms allow for the detection of subtle differences in the conserved IDRs of TFs as well as changes in variable IDRs, which can influence the DNA recognition and multifunctionality of TFs through direct or indirect mechanisms. Although strong correlations cannot be taken as evidence for causeand-effect relationships, we interpret our data to indicate that increasing TF disorder likely was an important factor contributing to the evolution of organismic complexity and not merely a concurrent unrelated effect of increasing organismic complexity.
000069776 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B18$$9info:eu-repo/grantAgreement/ES/MECD/PR2015-00353
000069776 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000069776 590__ $$a3.94$$b2017
000069776 591__ $$aGENETICS & HEREDITY$$b42 / 171 = 0.246$$c2017$$dQ1$$eT1
000069776 591__ $$aEVOLUTIONARY BIOLOGY$$b14 / 49 = 0.286$$c2017$$dQ2$$eT1
000069776 592__ $$a2.578$$b2017
000069776 593__ $$aGenetics$$c2017$$dQ1
000069776 593__ $$aEcology, Evolution, Behavior and Systematics$$c2017$$dQ1
000069776 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000069776 700__ $$aOldfield, C.J.
000069776 700__ $$aNiklas, K.J.
000069776 700__ $$aDunker, A.K.
000069776 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000069776 773__ $$g9, 5 (2017), 1248-1265$$pGENOME BIOLOGY AND EVOLUTION$$tGENOME BIOLOGY AND EVOLUTION$$x1759-6653
000069776 8564_ $$s1634625$$uhttps://zaguan.unizar.es/record/69776/files/texto_completo.pdf$$yVersión publicada
000069776 8564_ $$s114596$$uhttps://zaguan.unizar.es/record/69776/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000069776 909CO $$ooai:zaguan.unizar.es:69776$$particulos$$pdriver
000069776 951__ $$a2019-07-09-12:14:51
000069776 980__ $$aARTICLE