000069779 001__ 69779
000069779 005__ 20191212100704.0
000069779 0247_ $$2doi$$a10.1371/journal.pone.0193143
000069779 0248_ $$2sideral$$a104925
000069779 037__ $$aART-2018-104925
000069779 041__ $$aeng
000069779 100__ $$aDivo, M.J.
000069779 245__ $$aChronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort
000069779 260__ $$c2018
000069779 5060_ $$aAccess copy available to the general public$$fUnrestricted
000069779 5203_ $$aBackground Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of comorbidities characteristically affecting the elderly occur at an earlier age in subjects with the diagnosis of COPD. Methods and findings We included all subjects carrying the diagnosis of COPD (n = 27, 617), and a similar number of age and sex matched individuals without the diagnosis, extracted from the 727, 241 records of individuals 40 years and older included in the EpiChron Cohort (Aragon, Spain). We compared the cumulative number of comorbidities, their prevalence and the mortality risk between both groups. Using network analysis, we explored the connectivity between comorbidities and the most influential comorbidities in both groups. We divided the groups into 5 incremental age categories and compared their comorbidity networks. We then selected those comorbidities known to affect primarily the elderly and compared their prevalence across the 5 age groups. In addition, we replicated the analysis in the smokers'' subgroup to correct for the confounding effect of cigarette smoking. Subjects with COPD had more comorbidities and died at a younger age compared to controls. Comparison of both cohorts across 5 incremental age groups showed that the number of comorbidities, the prevalence of diseases characteristic of aging and network''s density for the COPD group aged 56-65 were similar to those of non-COPD 15 to 20 years older. The findings persisted after adjusting for smoking. Conclusion Multimorbidity increases with age but in patients carrying the diagnosis of COPD, these comorbidities are seen at an earlier age.
000069779 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI11-01126$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI12-02175$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-1940
000069779 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000069779 590__ $$a2.776$$b2018
000069779 591__ $$aMULTIDISCIPLINARY SCIENCES$$b23 / 69 = 0.333$$c2018$$dQ2$$eT2
000069779 592__ $$a1.1$$b2018
000069779 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2018$$dQ1
000069779 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000069779 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2018$$dQ1
000069779 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000069779 700__ $$aCelli, B.R.
000069779 700__ $$aPoblador-Plou, B.
000069779 700__ $$0(orcid)0000-0001-9064-9222$$aCalderon-Larranaga, A.
000069779 700__ $$ade-Torres, J.P.
000069779 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno-Feliu, L.A.$$uUniversidad de Zaragoza
000069779 700__ $$aBerto, J.
000069779 700__ $$aZulueta, J.J.
000069779 700__ $$aCasanova, C.
000069779 700__ $$aPinto-Plata, V.M.
000069779 700__ $$aCabrera-Lopez, C.
000069779 700__ $$aPolverino, F.
000069779 700__ $$aCarmona Pirez, J.
000069779 700__ $$0(orcid)0000-0002-5704-6056$$aPrados-Torres, A.
000069779 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J.M.$$uUniversidad de Zaragoza
000069779 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000069779 773__ $$g13, 2 (2018), e0193143[16 pp]$$pPLoS One$$tPloS one$$x1932-6203
000069779 8564_ $$s853074$$uhttps://zaguan.unizar.es/record/69779/files/texto_completo.pdf$$yVersión publicada
000069779 8564_ $$s109663$$uhttps://zaguan.unizar.es/record/69779/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000069779 909CO $$ooai:zaguan.unizar.es:69779$$particulos$$pdriver
000069779 951__ $$a2019-12-12-10:05:38
000069779 980__ $$aARTICLE