69934 20210125144518.0 doi 10.1109/TBME.2018.2821182 sideral 105386 ART-2018-105386 eng (orcid)0000-0002-1297-0691 Kontaxis, Spyridon Universidad de Zaragoza Assessment of quadratic nonlinear cardiorespiratory couplings during tilt table test by means of real wavelet biphase 2018 Access copy available to the general public Unrestricted In this paper a method for assessment of Quadratic Phase Coupling (QPC) between respiration and Heart Rate Variability (HRV) is presented. Methods: First, a method for QPC detection is proposed named Real Wavelet Biphase (RWB). Then, a method for QPC quantification is proposed based on the Normalized Wavelet Biamplitude (NWB). A simulation study has been conducted to test the reliability of RWB to identify QPC, even in the presence of constant delays between interacting oscillations, and to discriminate it from Quadratic Phase Uncoupling. Significant QPC was assessed based on surrogate data analysis. Then, quadratic cardiorespiratory couplings were studied during a tilt table test protocol of 17 young healthy subjects. Results: Simulation study showed that RWB is able to detect even weak QPC with delays in the range of 0 - 2 s, which are usual in the Autonomic Nervous System (ANS) control of heart rate. Results from the database revealed a significant reduction (p<0.05) of NWB between respiration and both low and high frequencies of HRV in head-up tilt position compared to early supine. Conclusion: The proposed technique detects and quantifies robustly QPC and is able to track the coupling between respiration and various HRV components during ANS changes. Significance: The proposed method can help to assess alternations of nonlinear cardiorespiratory interactions related to ANS dysfunction and physiological regulation of HRV in cardiovascular diseases. info:eu-repo/grantAgreement/ES/MINECO/TIN2014-5356-R This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 745755-WECARMON info:eu-repo/grantAgreement/EC/H2020/745755/EU/Wearable Cardiorespiratory Monitor/WECARMON info:eu-repo/grantAgreement/ES/DGA/T96 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.491 2018 ENGINEERING, BIOMEDICAL 11 / 80 = 0.138 2018 Q1 T1 1.256 2018 Biomedical Engineering 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0001-8742-0072 Lázaro, Jesús Universidad de Zaragoza (orcid)0000-0001-7285-0715 Gil, Eduardo Universidad de Zaragoza (orcid)0000-0003-3434-9254 Laguna, Pablo Universidad de Zaragoza (orcid)0000-0003-1272-0550 Bailón, Raquel Universidad de Zaragoza 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 66, 1 (2018), 187-198 IEEE trans. biomed. eng. IEEE Transactions on Biomedical Engineering 0018-9294 1007458 http://zaguan.unizar.es/record/69934/files/texto_completo.pdf Postprint 144583 http://zaguan.unizar.es/record/69934/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:69934 articulos driver 2021-01-25-14:37:57 ARTICLE