70176 20190709135452.0 doi 10.1016/j.placenta.2017.04.025 sideral 98961 ART-2017-98961 eng (orcid)0000-0002-0670-5541 Oros, D. Altered gene expression in human placenta after suspected preterm labour 2017 Access copy available to the general public Unrestricted Introduction Suspected preterm labour occurs in around 9% of pregnancies. However, almost two-thirds of women admitted for threatened preterm labour ultimately deliver at term and are considered risk-free for fetal development. Methods We examined placental and umbilical cord blood samples from preterm or term deliveries after threatened preterm labour as well as term deliveries without threatened preterm labour. We quantitatively analysed the mRNA expression of inflammatory markers (IL6, IFN?, and TNFa) and modulators of angiogenesis (FGF2, PGF, VEGFA, VEGFB, and VEGFR1). Results A total of 132 deliveries were analysed. Preterm delivery and term delivery after suspected preterm labour groups showed similar increases in TNFa expression compared with the term delivery control group in umbilical cord blood samples. Placental samples from preterm and term deliveries after suspected preterm labour exhibited significantly increased expression of TNFa and IL6 and decreased expression of IFN?. Suspected preterm labour was also associated with altered expression of angiogenic factors, although not all differences reached statistical significance. Discussion We found gene expression patterns indicative of inflammation in human placentas after suspected preterm labour regardless of whether the deliveries occurred preterm or at term. Similarly, a trend towards altered expression of angiogeneic factors was not limited to preterm birth. These findings suggest that the biological mechanisms underlying threatened preterm labour affect pregnancies independently of gestational age at birth. info:eu-repo/grantAgreement/ES/DGA/B87-2014 info:eu-repo/grantAgreement/ES/ISCIII/PI10-301 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.434 2017 DEVELOPMENTAL BIOLOGY 21 / 42 = 0.5 2017 Q2 T2 OBSTETRICS & GYNECOLOGY 29 / 81 = 0.358 2017 Q2 T2 REPRODUCTIVE BIOLOGY 16 / 29 = 0.552 2017 Q3 T2 1.223 2017 Obstetrics and Gynecology 2017 Q1 Reproductive Medicine 2017 Q1 Developmental Biology 2017 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Strunk, M. Breton, P. Paules, C. (orcid)0000-0001-5134-1006 Benito, R. Universidad de Zaragoza Moreno, E. Garcés, M. Godino, J. Schoorlemmer, J. Universidad de Zaragoza 1008 630 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Microbiología 1001 025 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Anatom.Anatom.Patológ.Com 55 (2017), 21-28 Placenta PLACENTA 0143-4004 1747212 http://zaguan.unizar.es/record/70176/files/texto_completo.pdf Postprint 56863 http://zaguan.unizar.es/record/70176/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:70176 articulos driver 2019-07-09-11:41:40 ARTICLE