000070257 001__ 70257
000070257 005__ 20200117213749.0
000070257 0247_ $$2doi$$a10.1371/journal.pntd.0006248
000070257 0248_ $$2sideral$$a105346
000070257 037__ $$aART-2018-105346
000070257 041__ $$aeng
000070257 100__ $$aSpengler, J.R.
000070257 245__ $$aHost preferences support the prominent role of Hyalomma ticks in the ecology of Crimean-Congo hemorrhagic fever
000070257 260__ $$c2018
000070257 5060_ $$aAccess copy available to the general public$$fUnrestricted
000070257 5203_ $$aCrimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic agent that is maintained in nature in an enzootic vertebrate-tick-vertebrate cycle. Hyalomma genus ticks have been implicated as the main CCHFV vector and are key in maintaining silent endemic foci. However, what contributes to their central role in CCHFV ecology is unclear. To assess the significance of host preferences of ticks in CCHFV ecology, we performed comparative analyses of hosts exploited by 133 species of ticks; these species represent 5 genera with reported geographical distribution over the range of CCHFV. We found that the composition of vertebrate hosts on which Hyalomma spp. feed is different than for other tick genera. Immatures of the genus Hyalomma feed preferentially on species of the orders Rodentia, Lagomorpha, and the class Aves, while adults concentrate mainly on the family Bovidae. With the exception of Aves, these hosts include the majority of the vertebrates consistently reported to be viremic upon CCHFV infection. While other tick genera also feed on these hosts, Hyalomma spp. almost completely concentrate their populations on them. Hyalomma spp. feed on less phylogenetically diverse hosts than any other tick genus, implying that this network of hosts has a low resilience. Indeed, removing the most prominent hosts quickly collapsed the network of parasitic interactions. These results support the intermittent activity of CCHFV foci: likely, populations of infected Hyalomma spp. ticks exceed the threshold of contact with humans only when these critical hosts reach adequate population density, accounting for the sporadic occurence of clinical tick-transmitted cases. Our data describe the association of vertebrate host preferences with the role of Hyalomma spp. ticks in maintaining endemic CCHFV foci, and highlight the importance of host-tick dynamics in pathogen ecology.
000070257 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000070257 590__ $$a4.487$$b2018
000070257 591__ $$aTROPICAL MEDICINE$$b1 / 21 = 0.048$$c2018$$dQ1$$eT1
000070257 591__ $$aPARASITOLOGY$$b4 / 36 = 0.111$$c2018$$dQ1$$eT1
000070257 592__ $$a2.669$$b2018
000070257 593__ $$aInfectious Diseases$$c2018$$dQ1
000070257 593__ $$aPublic Health, Environmental and Occupational Health$$c2018$$dQ1
000070257 593__ $$aPharmacology, Toxicology and Pharmaceutics (miscellaneous)$$c2018$$dQ1
000070257 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000070257 700__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, A.$$uUniversidad de Zaragoza
000070257 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000070257 773__ $$g12, 2 (2018), e0006248[17 pp]$$pPLoS negl. trop. dis.$$tPLoS Neglected Tropical Diseases$$x1935-2727
000070257 8564_ $$s624784$$uhttps://zaguan.unizar.es/record/70257/files/texto_completo.pdf$$yVersión publicada
000070257 8564_ $$s102024$$uhttps://zaguan.unizar.es/record/70257/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000070257 909CO $$ooai:zaguan.unizar.es:70257$$particulos$$pdriver
000070257 951__ $$a2020-01-17-21:31:34
000070257 980__ $$aARTICLE