70641 20201009175923.0 doi 10.17235/reed.2016.4327/2016 sideral 106014 ART-2016-106014 eng (orcid)0000-0001-8584-3979 Castro, Marta Universidad de Zaragoza Spasmolytic effect of Jasonia glutinosa on rodent intestine 2016 Access copy available to the general public Unrestricted Introduction: Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as "te de roca" (rock tea) but there is no scientific evidence about the effects of this plant. Aim: To evaluate the spasmolytic effect of rock tea. Methods: We have studied the in vitro effect of a rock tea extract on rat duodenum spontaneous contractions and the in vivo effect on mice gastrointestinal transit. Results: Rock tea extract reduced the spontaneous contractions of rat duodenal smooth muscle, inhibited KCl-induced contractions and blocked the contractions invoked by both extracellular Ca2+ and the agonist of L-type calcium channels Bay K8644. This inhibitory effect was similar to the one observed after the addition of the antagonist of L-type calcium channels verapamil. Rock tea did not modify gastrointestinal transit in healthy mice. However, after the treatment with dextran sulfate sodium, an inducer of colitis, rock tea extract reverted the increase in the gastrointestinal transit associated with this treatment. Conclusion: Rock tea extract relaxed duodenal smooth muscle via L-type calcium channels and normalized gastrointestinal transit in a model of colitis. These results may validate the traditional use of Jasonia glutinosa in patients with gastrointestinal alterations. Thus, rock tea may be used as a spasmolytic agent to treat gastrointestinal disorders. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA/E02 info:eu-repo/grantAgreement/ES/DGA/B61 info:eu-repo/semantics/openAccess by-sa http://creativecommons.org/licenses/by-sa/3.0/es/ 1.401 2016 GASTROENTEROLOGY & HEPATOLOGY 69 / 79 = 0.873 2016 Q4 T3 0.445 2016 Medicine (miscellaneous) 2016 Q2 Gastroenterology 2016 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ramón Giménez, Mariano (orcid)0000-0002-7972-7119 Les, Francisco Trejo, Lorena (orcid)0000-0002-7412-2073 Plaza, Miguel Ángel Universidad de Zaragoza López, Víctor (orcid)0000-0002-3917-4740 Murillo, María Divina (orcid)0000-0002-2231-7565 Valero, Marta Sofia Universidad de Zaragoza 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 108, 12 (2016), 785-789 Rev. esp. enferm. dig. REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS 1130-0108 636328 http://zaguan.unizar.es/record/70641/files/texto_completo.pdf Versión publicada 110741 http://zaguan.unizar.es/record/70641/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:70641 articulos driver 2020-10-09-17:47:10 ARTICLE