Potential benefits of melatonin in organ transplantation: a review

Esteban-Zubero, E. ; Garcia-Gil, F.A. (Universidad de Zaragoza) ; Lopez-Pingarron, L. (Universidad de Zaragoza) ; Alatorre-Jimenez, M.A. ; Iñnigo-Gil, P. (Universidad de Zaragoza) ; Tan, D.X. ; Garcia, J.J. (Universidad de Zaragoza) ; Reiter, R.J.

Resumen: Organ transplantation is a useful therapeutic tool for patients with end-stage organ failure; however, graft rejection is a major obstacle in terms of a successful treatment. Rejection is usually a consequence of a complex immunological and nonimmunological antigen-independent cascade of events, including free radical-mediated ischemia-reperfusion injury (IRI). To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. Melatonin (N-acetyl-5-methoxytryptamine) is a powerful antioxidant and ant-inflammatory agent synthesized from the essential amino acid L-tryptophan; it is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. Melatonin has proven to be a potentially useful therapeutic tool in the reduction of graft rejection. Its benefits are based on its direct actions as a free radical scavenger as well as its indirect antioxidative actions in the stimulation of the cellular antioxidant defense system. Moreover, it has significant anti-inflammatory activity. Melatonin has been found to improve the beneficial effects of preservation fluids when they are enriched with the indoleamine. This article reviews the experimental evidence that melatonin is useful in reducing graft failure, especially in cardiac, bone, otolaryngology, ovarian, testicular, lung, pancreas, kidney, and liver transplantation.

Idioma: Inglés

DOI: 10.1530/JOE-16-0117

Año: 2016

Publicado en: JOURNAL OF ENDOCRINOLOGY 229, 3 (2016), R129-R146
ISSN: 0022-0795

Factor impacto JCR: 4.706 (2016)

Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 26 / 138 = 0.188 (2016) - Q1 - T1

Factor impacto SCIMAGO: 2.013 - Endocrinology, Diabetes and Metabolism (Q1) - Endocrinology (Q1)

Tipo y forma: Review (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Cirugía (Dpto. Cirugía,Ginecol.Obstetr.)