000070684 001__ 70684 000070684 005__ 20200221144258.0 000070684 0247_ $$2doi$$a10.1016/j.mayocp.2016.04.024 000070684 0248_ $$2sideral$$a96677 000070684 037__ $$aART-2016-96677 000070684 041__ $$aeng 000070684 100__ $$aSantos-Lozano, A. 000070684 245__ $$aPhysical activity and Alzheimer disease: a protective association 000070684 260__ $$c2016 000070684 5060_ $$aAccess copy available to the general public$$fUnrestricted 000070684 5203_ $$aObjective To explore whether being physically active can decrease Alzheimer disease (AD) risk. Participants and Methods We conducted a meta-analysis of prospective observational cohort studies reporting the association between physical activity (PA) and incident AD. Relevant articles were identified by title and abstract in the electronic databases PubMed, ScienceDirect, and Scopus using the keywords Alzheimer, Alzheimer disease, Alzheimer''s, Alzheimer''s disease, physical activity, sport, exercise, sedentary, fitness, and combinations thereof for articles published in any language up to February 15, 2016. Criteria for consideration included division of the study cohort by PA levels and sample size specification for each PA level group, quantification (number) of persons who had development of AD, and PA assessment during time off work (not just work time). We followed the MOOSE (Meta-analyses of Observational Studies in Epidemiology) recommendations and used the Newcastle-Ottawa scale for study quality assessment. Results Ten high-quality studies were included in meta-analysis I (23, 345 participants). Follow-up ranged from 3.9 to 31 years, and the participants’ age ranged from 70 to 80 years. The pooled odds ratio for development of AD in participants who were more vs less physically active was 0.65 (95% CI, 0.56-0.74; P<.001; no publication bias P=.24] but with heterogeneity among studies I2=31.32%]). We could identify participants’ adherence to international PA recommendations in 5 studies, which constituted meta-analysis II (10, 615 participants). The pooled odds ratio for development of AD in participants who were active vs those who were inactive was 0.60 (95% CI, 0.51-0.71; P<.001; no publication bias P=.34] and no heterogeneity I2=5.63%]). Conclusion Although the limitations of self-reported PA data must be considered, regular PA performed by elderly people might play a certain protective role against AD. 000070684 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI12-00914 000070684 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000070684 590__ $$a6.686$$b2016 000070684 591__ $$aMEDICINE, GENERAL & INTERNAL$$b12 / 154 = 0.078$$c2016$$dQ1$$eT1 000070684 592__ $$a2.732$$b2016 000070684 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1 000070684 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/submittedVersion 000070684 700__ $$aPareja-Galeano, H. 000070684 700__ $$aSanchis-Gomar, F. 000070684 700__ $$aQuindós-Rubial, M. 000070684 700__ $$aFiuza-Luces, C. 000070684 700__ $$aCristi-Montero, C. 000070684 700__ $$aEmanuele, E. 000070684 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, N.$$uUniversidad de Zaragoza 000070684 700__ $$aLucia, A. 000070684 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor. 000070684 773__ $$g91, 8 (2016), 999-1020$$pMayo Clin. proc.$$tMAYO CLINIC PROCEEDINGS$$x0025-6196 000070684 8564_ $$s434268$$uhttps://zaguan.unizar.es/record/70684/files/texto_completo.pdf$$yPreprint 000070684 8564_ $$s48642$$uhttps://zaguan.unizar.es/record/70684/files/texto_completo.jpg?subformat=icon$$xicon$$yPreprint 000070684 909CO $$ooai:zaguan.unizar.es:70684$$particulos$$pdriver 000070684 951__ $$a2020-02-21-13:30:37 000070684 980__ $$aARTICLE