70684 20200221144258.0 doi 10.1016/j.mayocp.2016.04.024 sideral 96677 ART-2016-96677 eng Santos-Lozano, A. Physical activity and Alzheimer disease: a protective association 2016 Access copy available to the general public Unrestricted Objective To explore whether being physically active can decrease Alzheimer disease (AD) risk. Participants and Methods We conducted a meta-analysis of prospective observational cohort studies reporting the association between physical activity (PA) and incident AD. Relevant articles were identified by title and abstract in the electronic databases PubMed, ScienceDirect, and Scopus using the keywords Alzheimer, Alzheimer disease, Alzheimer''s, Alzheimer''s disease, physical activity, sport, exercise, sedentary, fitness, and combinations thereof for articles published in any language up to February 15, 2016. Criteria for consideration included division of the study cohort by PA levels and sample size specification for each PA level group, quantification (number) of persons who had development of AD, and PA assessment during time off work (not just work time). We followed the MOOSE (Meta-analyses of Observational Studies in Epidemiology) recommendations and used the Newcastle-Ottawa scale for study quality assessment. Results Ten high-quality studies were included in meta-analysis I (23, 345 participants). Follow-up ranged from 3.9 to 31 years, and the participants’ age ranged from 70 to 80 years. The pooled odds ratio for development of AD in participants who were more vs less physically active was 0.65 (95% CI, 0.56-0.74; P<.001; no publication bias P=.24] but with heterogeneity among studies I2=31.32%]). We could identify participants’ adherence to international PA recommendations in 5 studies, which constituted meta-analysis II (10, 615 participants). The pooled odds ratio for development of AD in participants who were active vs those who were inactive was 0.60 (95% CI, 0.51-0.71; P<.001; no publication bias P=.34] and no heterogeneity I2=5.63%]). Conclusion Although the limitations of self-reported PA data must be considered, regular PA performed by elderly people might play a certain protective role against AD. info:eu-repo/grantAgreement/ES/FIS/PI12-00914 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 6.686 2016 MEDICINE, GENERAL & INTERNAL 12 / 154 = 0.078 2016 Q1 T1 2.732 2016 Medicine (miscellaneous) 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion Pareja-Galeano, H. Sanchis-Gomar, F. Quindós-Rubial, M. Fiuza-Luces, C. Cristi-Montero, C. Emanuele, E. (orcid)0000-0001-8374-9081 Garatachea, N. Universidad de Zaragoza Lucia, A. 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 91, 8 (2016), 999-1020 Mayo Clin. proc. MAYO CLINIC PROCEEDINGS 0025-6196 434268 http://zaguan.unizar.es/record/70684/files/texto_completo.pdf Preprint 48642 http://zaguan.unizar.es/record/70684/files/texto_completo.jpg?subformat=icon icon Preprint oai:zaguan.unizar.es:70684 articulos driver 2020-02-21-13:30:37 ARTICLE