000070686 001__ 70686
000070686 005__ 20200221144318.0
000070686 0247_ $$2doi$$a10.1016/j.numecd.2016.07.010
000070686 0248_ $$2sideral$$a97049
000070686 037__ $$aART-2016-97049
000070686 041__ $$aeng
000070686 100__ $$aLabayen, I.
000070686 245__ $$aDietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: the HELENA cross-sectional study
000070686 260__ $$c2016
000070686 5060_ $$aAccess copy available to the general public$$fUnrestricted
000070686 5203_ $$aBackground and aims The fat mass and obesity associated gene (FTO) has been associated with obesity and dietary intake. The aims were: (i) To assess whether energy and macronutrient intakes were different across the FTOrs9939609 genotypes in adolescents, and (ii) to explore whether dietary fat intake modified the association of the rs9939609 polymorphism with adiposity. Methods and results The FTOrs9939609 polymorphism was genotyped in 652 adolescents (53% females, 14.8 ± 1.2 years, TT = 246, TA = 296, AA = 110). Energy and macronutrient intake were assessed by two non-consecutive 24 h-recalls. Weight, height, waist circumference and skinfold thicknesses were measured and body fat percent was calculated. Energy and macronutrient intake were similar across the FTOrs9939609 genotypes (P > 0.2). There were significant interactions between the FTO polymorphism and fat intake on adiposity estimates (P < 0.05). In adolescents whose fat intake was below 30% (N = 203), the A allele of rs9939609 was not associated with adiposity indices. In contrast, in adolescents whose fat intake was between 30% and 35% of energy (N = 190), the rs9939609 polymorphism was associated with a 1.9% higher body fat per risk allele (95%CI: 0.39, 3.33; P < 0.05), and in those whose fat intake was higher than 35% (N = 259), it was associated with a 2.8% higher body fat per risk allele (95%CI: 1.27, 4.43; P < 0.001). Conclusions These findings support the concept that the deleterious effect of the FTOrs9939609 polymorphism on adiposity is exacerbated in adolescents consuming high fat diets. In contrast, the consumption of low fat diets (<30% of energy) may attenuate the genetic predisposition to obesity in risk allele carriers.
000070686 536__ $$9info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERobn CB12-03-30038$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2010-05957$$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-6007034
000070686 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000070686 590__ $$a3.679$$b2016
000070686 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b42 / 126 = 0.333$$c2016$$dQ2$$eT2
000070686 591__ $$aNUTRITION & DIETETICS$$b21 / 81 = 0.259$$c2016$$dQ2$$eT1
000070686 591__ $$aENDOCRINOLOGY & METABOLISM$$b47 / 138 = 0.341$$c2016$$dQ2$$eT2
000070686 592__ $$a1.588$$b2016
000070686 593__ $$aCardiology and Cardiovascular Medicine$$c2016$$dQ1
000070686 593__ $$aNutrition and Dietetics$$c2016$$dQ1
000070686 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000070686 593__ $$aEndocrinology, Diabetes and Metabolism$$c2016$$dQ1
000070686 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000070686 700__ $$aRuiz, J. R.
000070686 700__ $$aHuybrechts, I.
000070686 700__ $$aOrtega, F. B.
000070686 700__ $$aArenaza, L.
000070686 700__ $$aGonzález-Gross, M.
000070686 700__ $$aWidhalm, K.
000070686 700__ $$aMolnar, D.
000070686 700__ $$aManios, Y.
000070686 700__ $$aDeHenauw, S.
000070686 700__ $$aMeirhaeghe, A.
000070686 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L. A.$$uUniversidad de Zaragoza
000070686 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000070686 773__ $$g26, 10 (2016), 937-943$$pNMCD, Nutr. Metab. Cardiovasc. Dis.$$tNUTRITION METABOLISM AND CARDIOVASCULAR DISEASES$$x0939-4753
000070686 8564_ $$s190317$$uhttps://zaguan.unizar.es/record/70686/files/texto_completo.pdf$$yPostprint
000070686 8564_ $$s53621$$uhttps://zaguan.unizar.es/record/70686/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000070686 909CO $$ooai:zaguan.unizar.es:70686$$particulos$$pdriver
000070686 951__ $$a2020-02-21-13:40:12
000070686 980__ $$aARTICLE