000070746 001__ 70746
000070746 005__ 20200324135214.0
000070746 0247_ $$2doi$$a10.3389/fphys.2016.00280
000070746 0248_ $$2sideral$$a105956
000070746 037__ $$aART-2016-105956
000070746 041__ $$aeng
000070746 100__ $$aMartínez-Herrero, Sonia
000070746 245__ $$aPrevention of Bone Loss in a Model of Postmenopausal Osteoporosis through Adrenomedullin Inhibition
000070746 260__ $$c2016
000070746 5060_ $$aAccess copy available to the general public$$fUnrestricted
000070746 5203_ $$aDespite recent advances in the understanding and treatment options for osteoporosis, this condition remains a serious public health issue. Adrenomedullin (AM) is a regulatory peptide with reported activity on bone remodeling. To better understand this relationship we built an inducible knockout for AM. An outstanding feature of knockout mice is their heavier weight due, in part, to the presence of denser bones. The femur of knockout animals was denser, had more trabeculae, and a thicker growth plate than wild type littermates. The endocrine influence of AM on bone seems to be elicited through an indirect mechanism involving, at least, the regulation of insulin, glucose, ghrelin, and calcitonin gene-related peptide (CGRP). To confirm the data we performed a pharmacological approach using the AM inhibitor 16311 in a mouse model of osteoporosis. Ovariectomized females showed significant bone mass loss, whereas ovariectomized females treated with 16311 had similar bone density to sham operated females. In conclusion, we propose the use of AM inhibitors for the treatment of osteoporosis and other conditions leading to the loss of bone mass.
000070746 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02166
000070746 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000070746 590__ $$a4.134$$b2016
000070746 591__ $$aPHYSIOLOGY$$b15 / 84 = 0.179$$c2016$$dQ1$$eT1
000070746 592__ $$a1.814$$b2016
000070746 593__ $$aPhysiology (medical)$$c2016$$dQ1
000070746 593__ $$aPhysiology$$c2016$$dQ1
000070746 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000070746 700__ $$aLarrayoz, Ignacio M.
000070746 700__ $$aOchoa-Callejero, Laura
000070746 700__ $$0(orcid)0000-0001-5376-4440$$aFernandez, Luis J.$$uUniversidad de Zaragoza
000070746 700__ $$aAllueva, Alexis
000070746 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, Ignacio$$uUniversidad de Zaragoza
000070746 700__ $$aMartinez, Alfredo
000070746 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000070746 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000070746 773__ $$g7 (2016), 280 [11 pp.]$$pFront. physiol.$$tFRONTIERS IN PHYSIOLOGY$$x1664-042X
000070746 8564_ $$s582466$$uhttps://zaguan.unizar.es/record/70746/files/texto_completo.pdf$$yVersión publicada
000070746 8564_ $$s103574$$uhttps://zaguan.unizar.es/record/70746/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000070746 909CO $$ooai:zaguan.unizar.es:70746$$particulos$$pdriver
000070746 951__ $$a2020-03-24-10:01:20
000070746 980__ $$aARTICLE