000070752 001__ 70752 000070752 005__ 20190220220035.0 000070752 0247_ $$2doi$$a10.1177/2045125315591925 000070752 0248_ $$2sideral$$a105966 000070752 037__ $$aART-2016-105966 000070752 041__ $$aeng 000070752 100__ $$aLozano, R. 000070752 245__ $$aEffect of clozapine on immunoglobulin M plasma levels 000070752 260__ $$c2016 000070752 5060_ $$aAccess copy available to the general public$$fUnrestricted 000070752 5203_ $$aClozapine is an atypical antipsychotic medication indicated for the treatment of patients who fail to respond to standard antipsychotic treatment. It possesses immunomodulatory properties and requires regular counts of white blood cells and absolute neutrophils. It has been reported to mediate several effects on humoral immunity, such as altering the levels of antibody-producing cytokines [Hinze-Selch et al. 1998]. Selective immunoglobulin M immunodeficiency (SIgMD) is a rare form of dysgammaglobulinaemia characterized by a selective, low level of immunoglobulin M (IgM) in conjunction with normal T cell numbers and function, and with no other identifiable immunodeficiencies. It can occur as either a primary or secondary condition and displays an estimated prevalence of 0.03%– 3%. Secondary SIgMD can be associated with malignancy, autoimmune disorders, gastrointestinal diseases and/or immunosuppressive treatments [Goldstein et al. 2006]... 000070752 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000070752 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion 000070752 700__ $$aMarin, R. 000070752 700__ $$aSantacruz, M.J. 000070752 700__ $$aPascual, A. 000070752 773__ $$g6, 1 (2016), 58-60$$tTHERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY$$x2045-1253 000070752 8564_ $$s63905$$uhttps://zaguan.unizar.es/record/70752/files/texto_completo.pdf$$yVersión publicada 000070752 8564_ $$s117234$$uhttps://zaguan.unizar.es/record/70752/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000070752 909CO $$ooai:zaguan.unizar.es:70752$$particulos$$pdriver 000070752 951__ $$a2018-05-23-14:35:20 000070752 980__ $$aARTICLE