000007077 001__ 7077
000007077 005__ 20170831220608.0
000007077 037__ $$aTAZ-TFM-2012-021
000007077 041__ $$aeng
000007077 1001_ $$aColmenares Quevedo, María Gracia
000007077 24500 $$aOrdered mesoporous silica monoliths: synthesis, preparation and potential applications
000007077 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2012
000007077 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/
000007077 520__ $$aThe work carried out was focused on the preparation of rigid porous silica monoliths, in order to investigate applications as controlled drug release matrices. All work was based on the hexagonally-ordered mesoporous SBA-15 materials, and monoliths were obtained by gel-casting procedures. SBA-15 powder was successfully synthesized and characterized using SEM and TEM imaging, nitrogen adsorption and small-angle X-ray diffraction. Synthesis yielded fibrous SBA-15 particles with diameters between 4,5 and 7,5µm and lengths between 75 and 105µm, and highly ordered cylindrical pores arranged in a hexagonal fashion with a diameter between 5,6 and 6,9 nm. Functionalization of SBA-15 powder was carried out using (3-Aminopropyl)triethoxysilane as a functionalizing agent, in order to test functionalization effects on drug release, and to prepare more stable monoliths. Monoliths were prepared using gel-casting procedures; a suspension of polyacrylamide precursors and powder SBA-15 was centrifuged in a glass mold, and polymer hardening and further removal of the polymer template yielded stable monoliths exhibiting a bimodal pore structure confirmed by intrusion characterization. Macroscopic dimensions of the monoliths were 3mm in diameter and approximately 6 mm in length, with macropores around 3 µm and the characteristic mesopores of SBA-15. Monoliths were also functionalized using (3-Aminopropyl)triethoxysilane. Drug loading for drug delivery experiments was carried out by placing as-synthesized and functionalized SBA-15 powders and monoliths in direct contact with a solution of a model antibiotic, namely cefuroxime sodium salt. Functionalized powders yielded the highest loads, followed by unmodified powders, modified monoliths and with as-synthesized monoliths exhibiting the lowest loads. Drug release experiments were focused on release of cefuroxime from as-synthesized and amino-functionalized SBA-15 powders and monoliths. Monoliths exhibit an initial burst release that was attributed to antibiotic loaded in the macroporous reservoirs, while a more controlled release was obtained from the powder counterparts.
000007077 521__ $$aMáster Universitario en Materiales Nanoestructurados para Aplicaciones Nanotecnológicas (Nanostructured Materials for Nanotechnology Applications)
000007077 540__ $$aDerechos regulados por licencia Creative Commons
000007077 700__ $$aArruebo Gordo, Manuel$$edir.
000007077 700__ $$aBalas Nieto, Francisco$$edir.
000007077 7102_ $$aUniversidad de Zaragoza$$bIngeniería Química y Tecnologías del Medio Ambiente$$cIngeniería Química
000007077 8560_ $$f641721@celes.unizar.es
000007077 8564_ $$s19980126$$uhttps://zaguan.unizar.es/record/7077/files/TAZ-TFM-2012-021.pdf$$yMemoria (eng)$$zMemoria (eng)
000007077 909CO $$ooai:zaguan.unizar.es:7077$$ptrabajos-fin-master$$pdriver
000007077 950__ $$a
000007077 980__ $$aTAZ$$bTFM$$cCIEN