000070879 001__ 70879 000070879 005__ 20191122145054.0 000070879 0247_ $$2doi$$a10.3390/computation6020033 000070879 0248_ $$2sideral$$a106349 000070879 037__ $$aART-2018-106349 000070879 041__ $$aeng 000070879 100__ $$0(orcid)0000-0002-3514-6443$$aSánchez, M.T. 000070879 245__ $$aModeling Confined Cell Migration Mediated by Cytoskeleton Dynamics 000070879 260__ $$c2018 000070879 5060_ $$aAccess copy available to the general public$$fUnrestricted 000070879 5203_ $$aCell migration is an important biological process that has generated increasing interest during the last several years. This process is based on three phases: protrusion at the front end of the cell, de-adhesion at the rear end and contraction of the cell body, all of them coordinated due to the polymerization/depolymerization of certain cytoskeletal proteins. The aim of this work is to present a mathematical model to simulate the actin polymerization/depolymerization process that regulates the final outcome of cell migration process, considering all the above phases, in a particular case: when the cell is confined in a microfluidic channel. Under these specific conditions, cell migration can be approximated by using one-dimensional simulations. We will propose a system of reaction-diffusion equations to simulate the behavior of the cytoskeletal proteins responsible for protrusion and contraction in the cell, coupled with the mechanical response of the cell, computing its deformations and stresses. Furthermore, a numerical procedure is presented in order to simulate the whole process in a moving and deformable domain corresponding to the cell body. 000070879 536__ $$9info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2015-64221-C2-1-R$$9info:eu-repo/grantAgreement/ES/UZ/CUD2013-10 000070879 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000070879 592__ $$a0.266$$b2018 000070879 593__ $$aApplied Mathematics$$c2018$$dQ2 000070879 593__ $$aTheoretical Computer Science$$c2018$$dQ2 000070879 593__ $$aModeling and Simulation$$c2018$$dQ2 000070879 593__ $$aComputer Science (miscellaneous)$$c2018$$dQ2 000070879 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000070879 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía Aznar, J.M.$$uUniversidad de Zaragoza 000070879 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000070879 773__ $$g6, 2 (2018), [15 pp.]$$pComputation$$tComputation$$x2079-3197 000070879 8564_ $$s413141$$uhttps://zaguan.unizar.es/record/70879/files/texto_completo.pdf$$yVersión publicada 000070879 8564_ $$s105561$$uhttps://zaguan.unizar.es/record/70879/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000070879 909CO $$ooai:zaguan.unizar.es:70879$$particulos$$pdriver 000070879 951__ $$a2019-11-22-14:44:48 000070879 980__ $$aARTICLE