70917 20191126134634.0 doi 10.3390/ijms19051449 sideral 106456 ART-2018-106456 eng Gallego-Lleyda, A. Universidad de Zaragoza Lipid nanoparticles decorated with TNF-related aptosis-inducing ligand (TRAIL) are more cytotoxic than soluble recombinant TRAIL in sarcoma 2018 Access copy available to the general public Unrestricted Sarcomas are rare and heterogeneous cancers classically associated with a poor outcome. Sarcomas are 1% of the cancer but recent estimations indicate that sarcomas account for 2% of the estimated cancer-related deaths. Traditional treatment with surgery, radiotherapy, and chemotherapy has improved the outcome for some types of sarcomas. However, novel therapeutic strategies to treat sarcomas are necessary. TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand initially described as capable of inducing apoptosis on tumor cell while sparing normal cells. Only few clinical trials have used TRAIL-based treatments in sarcoma, but they show only low or moderate efficacy of TRAIL. Consequently, novel TRAIL formulations with an improved TRAIL bioactivity are necessary. Our group has developed a novel TRAIL formulation based on tethering this death ligand on a lipid nanoparticle surface (LUV-TRAIL) resembling the physiological secretion of TRAIL as a trasmembrane protein inserted into the membrane of exosomes. We have already demonstrated that LUV-TRAIL shows an improved cytotoxic activity when compared to soluble recombinant TRAIL both in hematological malignancies and epithelial-derived cancers. In the present study, we have tested LUV-TRAIL in several human sarcoma tumor cell lines with different sensitivity to soluble recombinant TRAIL, finding that LUV-TRAIL was more efficient than soluble recombinant TRAIL. Moreover, combined treatment of LUV-TRAIL with distinct drugs proved to be especially effective, sensitizing even more resistant cell lines to TRAIL. info:eu-repo/grantAgreement/ES/ISCIII/PI16-00526 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.183 2018 CHEMISTRY, MULTIDISCIPLINARY 45 / 172 = 0.262 2018 Q2 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 77 / 294 = 0.262 2018 Q2 T1 1.312 2018 Catalysis 2018 Q1 Computer Science Applications 2018 Q1 Inorganic Chemistry 2018 Q1 Spectroscopy 2018 Q1 Molecular Biology 2018 Q1 Organic Chemistry 2018 Q1 Physical and Theoretical Chemistry 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion De Miguel, D. (orcid)0000-0002-5175-8394 Anel, A. Universidad de Zaragoza Martinez-Lostao, L. 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 19, 5 (2018), 1449 [18 pp] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 932838 http://zaguan.unizar.es/record/70917/files/texto_completo.pdf Versión publicada 109102 http://zaguan.unizar.es/record/70917/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:70917 articulos driver 2019-11-26-13:42:51 ARTICLE