000070919 001__ 70919 000070919 005__ 20200108100346.0 000070919 0247_ $$2doi$$a10.1093/ajcn/nqy028 000070919 0248_ $$2sideral$$a106484 000070919 037__ $$aART-2018-106484 000070919 041__ $$aeng 000070919 100__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M. 000070919 245__ $$aProspective association between added sugars and frailty in older adults 000070919 260__ $$c2018 000070919 5060_ $$aAccess copy available to the general public$$fUnrestricted 000070919 5203_ $$aBackground Sugar-sweetened beverages and added sugars (monosaccharides and disaccharides) in the diet are associated with obesity, diabetes, and cardiovascular disease, which are all risk factors for decline in physical function among older adults. Objective The aim of this study was to examine the association between added sugars in the diet and incidence of frailty in older people. Design Data were taken from 1973 Spanish adults =60 y old from the Seniors-ENRICA cohort. In 2008-2010 (baseline), consumption of added sugars (including those in fruit juices) was obtained using a validated diet history. Study participants were followed up until 2012-2013 to assess frailty based on Fried''s criteria. Statistical analyses were performed with logistic regression adjusted for age, sex, education, smoking status, body mass index, energy intake, self-reported comorbidities, Mediterranean Diet Adherence Score (excluding sweetened drinks and pastries), TV watching time, and leisure-Time physical activity. Results Compared with participants consuming <15 g/d added sugars (lowest tertile), those consuming =36 g/d (highest tertile) were more likely to develop frailty (OR: 2.27; 95% CI: 1.34, 3.90; P-Trend = 0.003). The frailty components "low physical activity" and "unintentional weight loss" increased dose dependently with added sugars. Association with frailty was strongest for sugars added during food production. Intake of sugars naturally appearing in foods was not associated with frailty. Conclusions The consumption of added sugars in the diet of older people was associated with frailty, mainly when present in processed foods. The frailty components that were most closely associated with added sugars were low level of physical activity and unintentional weight loss. Future research should determine whether there is a causal relation between added sugars and frailty. 000070919 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/16-1512$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI16-00609$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI14-00009$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-0288$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOS$$9info:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOS$$9info:eu-repo/grantAgreement/EC/FP7/305483/EU/Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative/FRAILOMIC 000070919 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000070919 590__ $$a6.568$$b2018 000070919 591__ $$aNUTRITION & DIETETICS$$b5 / 86 = 0.058$$c2018$$dQ1$$eT1 000070919 592__ $$a3.264$$b2018 000070919 593__ $$aNutrition and Dietetics$$c2018$$dQ1 000070919 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1 000070919 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000070919 700__ $$aRodriguez-Artalejo, F. 000070919 700__ $$aGuallar-Castillon, P. 000070919 700__ $$aBanegas, J.R. 000070919 700__ $$aGraciani, A. 000070919 700__ $$aGarcia-Esquinas, E. 000070919 700__ $$aOrdovas, J. 000070919 700__ $$aLopez-Garcia, E. 000070919 773__ $$g107, 5 (2018), 772-779$$pAm. j. clin. nutr.$$tAmerican Journal of Clinical Nutrition$$x0002-9165 000070919 8564_ $$s221195$$uhttps://zaguan.unizar.es/record/70919/files/texto_completo.pdf$$yVersión publicada 000070919 8564_ $$s112875$$uhttps://zaguan.unizar.es/record/70919/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000070919 909CO $$ooai:zaguan.unizar.es:70919$$particulos$$pdriver 000070919 951__ $$a2020-01-08-09:30:01 000070919 980__ $$aARTICLE