70919 20200108100346.0 doi 10.1093/ajcn/nqy028 sideral 106484 ART-2018-106484 eng (orcid)0000-0003-3963-0846 Laclaustra, M. Prospective association between added sugars and frailty in older adults 2018 Access copy available to the general public Unrestricted Background Sugar-sweetened beverages and added sugars (monosaccharides and disaccharides) in the diet are associated with obesity, diabetes, and cardiovascular disease, which are all risk factors for decline in physical function among older adults. Objective The aim of this study was to examine the association between added sugars in the diet and incidence of frailty in older people. Design Data were taken from 1973 Spanish adults =60 y old from the Seniors-ENRICA cohort. In 2008-2010 (baseline), consumption of added sugars (including those in fruit juices) was obtained using a validated diet history. Study participants were followed up until 2012-2013 to assess frailty based on Fried''s criteria. Statistical analyses were performed with logistic regression adjusted for age, sex, education, smoking status, body mass index, energy intake, self-reported comorbidities, Mediterranean Diet Adherence Score (excluding sweetened drinks and pastries), TV watching time, and leisure-Time physical activity. Results Compared with participants consuming <15 g/d added sugars (lowest tertile), those consuming =36 g/d (highest tertile) were more likely to develop frailty (OR: 2.27; 95% CI: 1.34, 3.90; P-Trend = 0.003). The frailty components "low physical activity" and "unintentional weight loss" increased dose dependently with added sugars. Association with frailty was strongest for sugars added during food production. Intake of sugars naturally appearing in foods was not associated with frailty. Conclusions The consumption of added sugars in the diet of older people was associated with frailty, mainly when present in processed foods. The frailty components that were most closely associated with added sugars were low level of physical activity and unintentional weight loss. Future research should determine whether there is a causal relation between added sugars and frailty. info:eu-repo/grantAgreement/ES/ISCIII/FIS/16-1512 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI16-00609 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI14-00009 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-0288 This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOS info:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOS info:eu-repo/grantAgreement/EC/FP7/305483/EU/Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative/FRAILOMIC info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 6.568 2018 NUTRITION & DIETETICS 5 / 86 = 0.058 2018 Q1 T1 3.264 2018 Nutrition and Dietetics 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rodriguez-Artalejo, F. Guallar-Castillon, P. Banegas, J.R. Graciani, A. Garcia-Esquinas, E. Ordovas, J. Lopez-Garcia, E. 107, 5 (2018), 772-779 Am. j. clin. nutr. American Journal of Clinical Nutrition 0002-9165 221195 http://zaguan.unizar.es/record/70919/files/texto_completo.pdf Versión publicada 112875 http://zaguan.unizar.es/record/70919/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:70919 articulos driver 2020-01-08-09:30:01 ARTICLE