000070932 001__ 70932
000070932 005__ 20191127155458.0
000070932 0247_ $$2doi$$a10.18632/oncotarget.25144
000070932 0248_ $$2sideral$$a106499
000070932 037__ $$aART-2018-106499
000070932 041__ $$aeng
000070932 100__ $$aGutierrez-Camino, A.
000070932 245__ $$aInvolvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk
000070932 260__ $$c2018
000070932 5060_ $$aAccess copy available to the general public$$fUnrestricted
000070932 5203_ $$aAcute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes, including those involved in B-cell maturation, differentiation and proliferation. Genetic variants in miRNAs can alter their own levels or function, affecting their target gene expression, and then, may affect ALL risk. Therefore, the aim of this study was to determine the role of miRNA genetic variants in B-ALL susceptibility. We analyzed all variants in pre-miRNAs (MAF > 1%) in two independent cohorts from Spain and Slovenia and inferred their functional effect by in silico analysis. SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway. These SNPs could be novel markers for ALL susceptibility.
000070932 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000070932 592__ $$a1.575$$b2018
000070932 593__ $$aOncology$$c2018$$dQ1
000070932 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000070932 700__ $$aMartin-Guerrero, I.
000070932 700__ $$aDolzan, V.
000070932 700__ $$aJazbec, J.
000070932 700__ $$aCarbone-Bañeres, A.
000070932 700__ $$ade Andoin, N.G.
000070932 700__ $$aSastre, A.
000070932 700__ $$aAstigarraga, I.
000070932 700__ $$aNavajas, A.
000070932 700__ $$aGarcia-Orad, A.
000070932 773__ $$g9, 33 (2018), 22907-22914$$pONCOTARGET$$tOncotarget$$x1949-2553
000070932 8564_ $$s617841$$uhttps://zaguan.unizar.es/record/70932/files/texto_completo.pdf$$yVersión publicada
000070932 8564_ $$s120252$$uhttps://zaguan.unizar.es/record/70932/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000070932 909CO $$ooai:zaguan.unizar.es:70932$$particulos$$pdriver
000070932 951__ $$a2019-11-27-15:48:36
000070932 980__ $$aARTICLE