70981 20190709135457.0 doi 10.1016/j.cej.2017.02.003 sideral 98996 ART-2017-98996 eng (orcid)0000-0002-6277-7996 Larrea, A. Efficient production of hybrid bio-nanomaterials by continuous microchannel emulsification: Dye-doped SiO2 and Au-PLGA nanoparticles 2017 Access copy available to the general public Unrestricted A novel microfluidic system was designed to produce in a continuous manner hybrid nanomaterials using the microchannel double w/o/w emulsification technique. Double w/o/w nanoemulsions were produced combining two inter-digital micromixers that afford working in continuous flow and with a high reproducibility and control on the reaction conditions. High throughput production of two hybrid nanomaterials, dye-doped SiO2 (4 mg/min) and Au-loaded poly(lactic-co-glycolic) acid (PLGA) (168 mg/min) nanoparticles, were achieved, showing the resulting nanomaterials excellent and reproducible optical properties and tunable loading. These hybrid nanomaterials could be potentially used in different biomedical applications. In addition, the microfluidic system designed for carrying out double emulsification enabled to decrease the particle size distribution of dye-doped SiO2 nanoparticles (NPs) up to 20 nm and to improve the Au NPs loading efficiency in Au-loaded PLGA hybrid nanoparticles. The excellent control achieved in the Au NPs loading allowed tuning the payload on demand. Finally, the microfluidic system designed in this work overpasses the productivity described in previously published batch-type reactors, while assuring the same properties of the resulting hybrid nanomaterials. info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO info:eu-repo/grantAgreement/ES/DGA/FSE info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 6.735 2017 ENGINEERING, ENVIRONMENTAL 3 / 50 = 0.06 2017 Q1 T1 ENGINEERING, CHEMICAL 7 / 137 = 0.051 2017 Q1 T1 1.863 2017 Chemical Engineering (miscellaneous) 2017 Q1 Industrial and Manufacturing Engineering 2017 Q1 Environmental Chemistry 2017 Q1 Chemistry (miscellaneous) 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-8787-117X Clemente, A. Universidad de Zaragoza Luque-Michel, E. (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 316 (2017), 663-672 Chem. eng. j. Chemical Engineering Journal 1385-8947 658398 http://zaguan.unizar.es/record/70981/files/texto_completo.pdf Postprint 50697 http://zaguan.unizar.es/record/70981/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:70981 articulos driver 2019-07-09-11:44:04 ARTICLE