71103 20190709135513.0 doi 10.1007/s10439-017-1864-y sideral 99504 ART-2017-99504 eng (orcid)0000-0003-4068-127X Bolea, Juan Universidad de Zaragoza Pulse rate and transit time analysis to predict hypotension events after spinal anesthesia during programmed cesarean labor 2017 Access copy available to the general public Unrestricted Prophylactic treatment has been proved to reduce hypotension incidence after spinal anesthesia during cesarean labor. However, the use of pharmacological prophylaxis could carry out undesirable side-effects on mother and fetus. Thus, the prediction of hypotension becomes an important challenge. Hypotension events are hypothesized to be related to a malfunctioning of autonomic nervous system (ANS) regulation of blood pressure. In this work, ANS responses to positional changes of 51 pregnant women programmed for a cesarean labor were explored for hypotension prediction. Lateral and supine decubitus, and sitting position were considered while electrocardiographic and pulse photoplethysmographic signals were recorded. Features based on heart rate variability, pulse rate variability (PRV) and pulse transit time (PTT) analysis were used in a logistic regression classifier. The results showed that PRV irregularity changes, assessed by approximate entropy, from supine to lateral decubitus, and standard deviation of PTT in supine decubitus were found as the combination of features that achieved the best classification results sensitivity of 76%, specificity of 70% and accuracy of 72%, being normotensive the positive class. Peripheral regulation and blood pressure changes, measured by PRV and PTT analysis, could help to predict hypotension events reducing prophylactic side-effects in the low-risk population. info:eu-repo/grantAgreement/ES/DGA/T96 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI10-02851 info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R info:eu-repo/grantAgreement/ES/MINECO/TIN2014-5356-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.405 2017 ENGINEERING, BIOMEDICAL 16 / 78 = 0.205 2017 Q1 T1 1.042 2017 Biomedical Engineering 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0001-8742-0072 Lázaro, Jesús Universidad de Zaragoza (orcid)0000-0001-7285-0715 Gil, Eduardo Universidad de Zaragoza Rovira, Eva Remartínez, José M. Universidad de Zaragoza (orcid)0000-0003-3434-9254 Laguna, Pablo Universidad de Zaragoza (orcid)0000-0002-1960-407X Pueyo, Esther Universidad de Zaragoza (orcid)0000-0002-6410-0495 Navarro, Augusto (orcid)0000-0003-1272-0550 Bailón, Raquel Universidad de Zaragoza 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 45, 9 (2017), 2253–2263 Ann. biomed. eng. ANNALS OF BIOMEDICAL ENGINEERING 0090-6964 483007 http://zaguan.unizar.es/record/71103/files/texto_completo.pdf Postprint 38781 http://zaguan.unizar.es/record/71103/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:71103 articulos driver 2019-07-09-11:53:35 ARTICLE