000071187 001__ 71187
000071187 005__ 20200117221603.0
000071187 0247_ $$2doi$$a10.1038/s41598-018-28394-x
000071187 0248_ $$2sideral$$a106915
000071187 037__ $$aART-2018-106915
000071187 041__ $$aeng
000071187 100__ $$0(orcid)0000-0002-9250-9060$$aSegura, Francisco$$uUniversidad de Zaragoza
000071187 245__ $$aDevelopment of optokinetic tracking software for objective evaluation of visual function in rodents
000071187 260__ $$c2018
000071187 5060_ $$aAccess copy available to the general public$$fUnrestricted
000071187 5203_ $$aThe aim of this study was to develop software that performs the optokinetic tracking assessment without the involvement of experimenters to increase the objectivity of the test. To check the effectiveness of the software, several videos were analyzed and the results were compared to those produced by two experimenters. Videos consisted of visual acuity and contrast sensitivity tests on normal animals and pigmented P23H rats (animal model of retinitis pigmentosa). Our software showed a reasonably high success rate: in approximately 78% of the cases, both the software program and the experimenters were in agreement, including the direction of rotation. The software detected 7% false positive cases, 10% false negative cases, and it was wrong in 5% of the cases. Decrease in visual function with age in pigmented P23H rats was observed from the first time interval, although minimum thresholds were found in visual parameters at advanced ages. We developed simple software based on current functions included in the Matlab image processing toolbox that was able to recognize, with a reasonably high percentage of success, the subtle head movements of the rodent produced when visual perception of the optokinetic optotype occurs.
000071187 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B99$$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0016$$9info:eu-repo/grantAgreement/ES/MINECO/FIS2016-77319
000071187 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000071187 590__ $$a4.011$$b2018
000071187 591__ $$aMULTIDISCIPLINARY SCIENCES$$b14 / 69 = 0.203$$c2018$$dQ1$$eT1
000071187 592__ $$a1.414$$b2018
000071187 593__ $$aMultidisciplinary$$c2018$$dQ1
000071187 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000071187 700__ $$aArines, Justo
000071187 700__ $$0(orcid)0000-0002-5621-1937$$aSánchez-Cano, Ana$$uUniversidad de Zaragoza
000071187 700__ $$0(orcid)0000-0002-9261-0302$$aPerdices, Lorena
000071187 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000071187 700__ $$0(orcid)0000-0003-2656-6750$$aFuentes-Broto, Lorena$$uUniversidad de Zaragoza
000071187 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000071187 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000071187 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000071187 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000071187 773__ $$g8, 1 (2018), 10009 [11 p.]$$pSci. rep.$$tSCIENTIFIC REPORTS$$x2045-2322
000071187 8564_ $$s2062634$$uhttps://zaguan.unizar.es/record/71187/files/texto_completo.pdf$$yVersión publicada
000071187 8564_ $$s110785$$uhttps://zaguan.unizar.es/record/71187/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000071187 909CO $$ooai:zaguan.unizar.es:71187$$particulos$$pdriver
000071187 951__ $$a2020-01-17-21:44:02
000071187 980__ $$aARTICLE