000074851 001__ 74851
000074851 005__ 20200324135213.0
000074851 0247_ $$2doi$$a10.1016/j.jinorgbio.2017.08.020
000074851 0248_ $$2sideral$$a101468
000074851 037__ $$aART-2017-101468
000074851 041__ $$aeng
000074851 100__ $$aMármol, Inés$$uUniversidad de Zaragoza
000074851 245__ $$aAlkynyl gold(I) complex triggers necroptosis via ROS generation in colorectal carcinoma cells
000074851 260__ $$c2017
000074851 5060_ $$aAccess copy available to the general public$$fUnrestricted
000074851 5203_ $$aGiven the rise of apoptosis-resistant tumors, there exist a growing interest in developing new drugs capable of inducing different types of cell death to reduce colorectal cancer-related death rates. As apoptosis and necroptosis do not share cellular machinery, necroptosis induction may have a great therapeutic potential on those apoptosis- resistant cancers, despite the inflammatory effects associated with it. We have synthesized an alkynyl gold(I) complex [Au(CC-2-NC5H4)(PTA)] whose anticancer effect was tested on the colorectal adenocarcinoma Caco-2 cell line. With regard to its mechanism of action, this gold complex enters the mitochondria and disrupts its normal function, leading to an increase in ROS production, which triggers necroptosis. Necroptosis induction has been found dependent of TNF-a (Tumor necrosisfactor a) and TNFR1(Tumor necrosisfactor receptor 1) binding, RIP1(Receptor-Interacting Protein 1) activation and NF-¿B (Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells) signaling. Moreover, the antitumor potential of [Au(CC-2-NC5H4)(PTA)] has also been confirmed on the 3D cancer model spheroid. Overall, the obtained data show firstly that gold complexes might have the ability of inducing necroptosis, and secondarily that our compound [Au(CC-2-NC5H4)(PTA)] is an interesting alternative to current chemotherapy drugs in cases of apoptosis resistance.
000074851 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A32$$9info:eu-repo/grantAgreement/ES/DGA/E104$$9info:eu-repo/grantAgreement/ES/MEC/FPU12-05640$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R
000074851 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000074851 590__ $$a3.063$$b2017
000074851 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b10 / 45 = 0.222$$c2017$$dQ1$$eT1
000074851 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b137 / 292 = 0.469$$c2017$$dQ2$$eT2
000074851 592__ $$a0.743$$b2017
000074851 593__ $$aInorganic Chemistry$$c2017$$dQ2
000074851 593__ $$aBiochemistry$$c2017$$dQ3
000074851 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000074851 700__ $$0(orcid)0000-0003-3660-8651$$aVirumbrales-Muñoz, María$$uUniversidad de Zaragoza
000074851 700__ $$aQuero, Javier
000074851 700__ $$aSánchez-de-Diego, Cristina
000074851 700__ $$0(orcid)0000-0001-5376-4440$$aFernández, Luis$$uUniversidad de Zaragoza
000074851 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, Ignacio$$uUniversidad de Zaragoza
000074851 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, Elena$$uUniversidad de Zaragoza
000074851 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez-Yoldi, María Jesús$$uUniversidad de Zaragoza
000074851 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000074851 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000074851 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000074851 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000074851 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000074851 773__ $$g176 (2017), 123-133$$pJ. inorg. biochem.$$tJOURNAL OF INORGANIC BIOCHEMISTRY$$x0162-0134
000074851 8564_ $$s2156266$$uhttps://zaguan.unizar.es/record/74851/files/texto_completo.pdf$$yPostprint
000074851 8564_ $$s34472$$uhttps://zaguan.unizar.es/record/74851/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000074851 909CO $$ooai:zaguan.unizar.es:74851$$particulos$$pdriver
000074851 951__ $$a2020-03-24-10:01:09
000074851 980__ $$aARTICLE