000074863 001__ 74863
000074863 005__ 20200117221636.0
000074863 0247_ $$2doi$$a10.1371/journal.pone.0198397
000074863 0248_ $$2sideral$$a107179
000074863 037__ $$aART-2018-107179
000074863 041__ $$aeng
000074863 100__ $$0(orcid)0000-0001-5320-7839$$aBambo, M.P.$$uUniversidad de Zaragoza
000074863 245__ $$aDiagnostic ability of inner macular layers to discriminate early glaucomatous eyes using vertical and horizontal B-scan posterior pole protocols
000074863 260__ $$c2018
000074863 5060_ $$aAccess copy available to the general public$$fUnrestricted
000074863 5203_ $$aPurpose To evaluate the diagnostic ability of macular ganglion cell (mGCL) and macular retinal nerve fiber (mRNFL) layers, to detect early glaucomatous eyes, using the new segmentation software of Spectralis optical coherence tomography (OCT) device (Heidelberg Engineering). Methods A total of 83 eyes from 83 subjects were included in this observational, prospective cross-sectional study: 43 healthy controls and 40 early primary open-angle glaucoma (POAG) patients. All participants were examined using the Horizontal and Vertical Posterior Pole protocols, and the peripapillary RNFL (pRNFL) protocol of Spectralis OCT device. The new automated retinal segmentation software was applied to horizontal and vertical macular B-scans to determine mGCL and mRNFL thicknesses in each one of the 9 sectors of the Early Treatment Diagnostic Retinopathy Study circle. Thickness of each layer was compared between groups, and the sectors with better area under the receiver operating characteristic curve (AUC) were identified. Results mGCL was significantly thinner in the POAG group, especially in outer and inner temporal sectors (p<0.001); and mRNFL was significantly thinner in the POAG group in the outer inferior and the outer superior sector (p<0.001). Diagnostic accuracy of inner macular layers was good, and in general mGCL was superior to mRNFL. pRNFL obtained the best diagnostic capability (AUC, 0.886). Horizontal and vertical Posterior Pole protocols performed similarly. Conclusions Inner macular layers using either horizontal or vertical B-scans, especially temporal sectors of mGCL, have good diagnostic capability to differentiate early glaucomatous eyes from control eyes; however, pRNFL has the highest diagnostic sensitivity for glaucoma detection.
000074863 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000074863 590__ $$a2.776$$b2018
000074863 591__ $$aMULTIDISCIPLINARY SCIENCES$$b23 / 69 = 0.333$$c2018$$dQ2$$eT2
000074863 592__ $$a1.1$$b2018
000074863 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2018$$dQ1
000074863 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000074863 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2018$$dQ1
000074863 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000074863 700__ $$0(orcid)0000-0001-8769-3441$$aCameo, B.$$uUniversidad de Zaragoza
000074863 700__ $$aHernandez, R.$$uUniversidad de Zaragoza
000074863 700__ $$aFuentemilla, E.
000074863 700__ $$0(orcid)0000-0001-8563-3437$$aGüerri, N.$$uUniversidad de Zaragoza
000074863 700__ $$0(orcid)0000-0001-7517-4644$$aFerrandez, B.$$uUniversidad de Zaragoza
000074863 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000074863 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000074863 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000074863 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000074863 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000074863 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000074863 773__ $$g13, 6 (2018), 0198397 [13 pp]$$pPLoS One$$tPloS one$$x1932-6203
000074863 8564_ $$s7578136$$uhttps://zaguan.unizar.es/record/74863/files/texto_completo.pdf$$yVersión publicada
000074863 8564_ $$s91545$$uhttps://zaguan.unizar.es/record/74863/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000074863 909CO $$ooai:zaguan.unizar.es:74863$$particulos$$pdriver
000074863 951__ $$a2020-01-17-22:02:11
000074863 980__ $$aARTICLE