000074877 001__ 74877
000074877 005__ 20180920100718.0
000074877 0247_ $$2doi$$a10.4236/abb.2014.56063
000074877 0248_ $$2sideral$$a87917
000074877 037__ $$aART-2014-87917
000074877 041__ $$aeng
000074877 100__ $$aLopez, Enrique
000074877 245__ $$aProbability of osteoporotic vertebral fractures assessment based on DXA measurements and finite element simulation
000074877 260__ $$c2014
000074877 5060_ $$aAccess copy available to the general public$$fUnrestricted
000074877 5203_ $$aOsteoporotic vertebral fractures represent major cause of disability, loss of quality of life and even mortality among the elderly population. Decisions on drug therapy are based on the assessment of risk factors for fracture, from bone mineral density measurements. The combination of biomechanical models with clinical studies could better estimate bone strength and support the specialists in their decision. A model to assess the probability of fracture, based on the Damage and Fracture Mechanics has been developed, evaluating the mechanical magnitudes involved in the fracture process from clinical bone mineral density measurements. The model is intended for simulating the degenerative process in the skeleton, with the consequent lost of bone mass and hence the decrease of its mechanical resistance which enables the fracture due to different traumatisms. Clinical studies were chosen, both in non-treatment conditions and receiving drug therapy, and fitted to specific patients according their actual bone mineral density measures. The predictive model is applied in a finite element simulation of the lumbar spine. The fracture zone would be determined according loading scenario (fall, impact, accidental loads, etc.), using the mechanical properties of bone obtained from the evolutionary model corresponding to the considered time. Bone mineral density evolution in untreated patients and in those under different treatments was analyzed. Evolutionary curves of fracture probability were obtained from the evolution of mechanical damage. The evolutionary curve of the untreated group of patients presented a marked increase of the fracture probability, while the curves of patients under drug treatment showed variable decreased risks, depending on the therapy type. The finite element model allowed obtaining detailed maps of damage and fracture probability, identifying high-risk local zones at vertebral body, which are the usual localization of osteoporotic vertebral fractures. The developed model is suitable for being used in individualized cases. The model might better identify at-risk individuals in early stages of osteoporosis and might be helpful for treatment decisions.
000074877 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000074877 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000074877 700__ $$aIbarz, Elena
000074877 700__ $$0(orcid)0000-0002-8643-7558$$aHerrera, Antonio$$uUniversidad de Zaragoza
000074877 700__ $$0(orcid)0000-0002-8235-9580$$aMateo, Jesus
000074877 700__ $$aLobo-Escolar, Antonio
000074877 700__ $$0(orcid)0000-0002-3613-4209$$aPuértolas, Sergio$$uUniversidad de Zaragoza
000074877 700__ $$aGracia, Luis
000074877 7102_ $$11004$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Traumatología y Ortopedia
000074877 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000074877 773__ $$g5 (2014), 527-545$$pAdv. Biosci. Biotechnol.$$tAdvances in Bioscience and Biotechnology$$x2156-8456
000074877 8564_ $$s1339788$$uhttps://zaguan.unizar.es/record/74877/files/texto_completo.pdf$$yVersión publicada
000074877 8564_ $$s97509$$uhttps://zaguan.unizar.es/record/74877/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000074877 909CO $$ooai:zaguan.unizar.es:74877$$particulos$$pdriver
000074877 951__ $$a2018-09-20-08:15:15
000074877 980__ $$aARTICLE