74907 20190709135447.0 doi 10.1016/j.eurpolymj.2017.09.020 sideral 101528 ART-2017-101528 eng Kyziol, Agnieszka Preparation and characterization of electrospun alginate nanofibers loaded with ciprofloxacin hydrochloride 2017 Access copy available to the general public Unrestricted Alginate nanofibers were prepared in the presence of poly(ethylene oxide) (PEO), a surfactant Pluronic F-127, and a model drug (ciprofloxacin hydrochloride, CpHCl), all mixed prior to electrospinning. It was demonstrated that addition of a carrier polymer (PEO) and a small amount of surfactant are necessary to obtain uniform alginate fibers with cylindrical shape and regular morphology. Importantly, PEO was completely removed from the resulting nanofibers during cross-linking and stabilization post-treatment. The stable alginate fibers loaded with CpHCl were examined by scanning electron microscopy and the average diameter of the fibers ranged from 109 nm (unloaded fibers) to 161 nm (loaded fibers). The release of a studied antibiotic from the nanofibers, characterized by a final loading efficiency of 51%, was tested in physiological conditions. It was revealed that ca. 24% of CpHCl is released during first 20 h with combined transport mechanism, however with the predominant contribution of Fickian diffusion. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.741 2017 POLYMER SCIENCE 12 / 87 = 0.138 2017 Q1 T1 0.996 2017 Organic Chemistry 2017 Q1 Polymers and Plastics 2017 Q1 Physics and Astronomy (miscellaneous) 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Michna, Justyn (orcid)0000-0002-6336-7542 Moreno Vidorreta, Iván (orcid)0000-0002-0272-3152 Gamez, Enrique Universidad de Zaragoza (orcid)0000-0002-2966-9088 Irusta, Silvia Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 96 (2017), 350-360 Eur. Polym. J. EUROPEAN POLYMER JOURNAL 0014-3057 1035182 http://zaguan.unizar.es/record/74907/files/texto_completo.pdf Postprint 69954 http://zaguan.unizar.es/record/74907/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:74907 articulos driver 2019-07-09-11:39:13 ARTICLE