doi:10.1038/s41598-018-29985-4engGarcía-Esquinas, E.Ortolá, R.Galán, I.Soler-Vila, H.Laclaustra, M.Rodríguez-Artalejo, F.Moderate alcohol drinking is not associated with risk of depression in older adultsART-2018-107667The scarce research on the effects of moderate alcohol consumption on mental health among older adults suggests a protective effect against depression. We prospectively examined the association between patterns of moderate alcohol consumption, depression and psychological distress, using information from 5, 299 community-dwelling older adults from the ELSA and Seniors-ENRICA cohorts. A Mediterranean drinking pattern (MDP) was defined as moderate alcohol intake (<40 g/day for men; <24 g/day for women) with a preference for wine and drinking only with meals. Depression was ascertained with the 10-item Geriatric Depression Scale (GDS-10), a self-report of clinically-diagnosed depression, or being on anti-depressant medication (Seniors-ENRICA); and with the 8-item Center for Epidemiologic Studies Depression Scale (CES-D) (ELSA). Psychological distress was assessed with the General Health Questionnaire-12 (GHQ-12). Compared to never drinkers, moderate drinkers showed comparable scores on the ENRICA-GDS-10 (PRR (95%CI): 1.03 (0.84–1.26)), the ENRICA-GHQ-12 (0.88 (0.73–1.06)), the ELSA-CES-D (0.92 (0.79–1.06)) and the ELSA-GHQ-12 (0.75 (0.55–1.01). The MDP was not associated with the GDS-10 or GHQ-12 scores, or with clinically-diagnosed depression; however drinkers with a preference for wine showed an increased number of psychological distress symptoms (1.31 (1.03–1.66)). In conclusion, we found no consistent protective association between moderate alcohol consumption and depression in older adults.2018http://zaguan.unizar.es/record/7495410.1038/s41598-018-29985-4http://zaguan.unizar.es/record/74954oai:zaguan.unizar.es:74954info:eu-repo/grantAgreement/ES/MSCBS/Plan Nacional sobre Drogas 02-2014info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI16-00609info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI12-1166This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOSinfo:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOSinfo:eu-repo/grantAgreement/EC/FP7/305483/EU/Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative/FRAILOMICSCIENTIFIC REPORTS 8, 1 (2018), 11512 [10 pp]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess