74954 20200117221609.0 doi 10.1038/s41598-018-29985-4 sideral 107667 ART-2018-107667 eng García-Esquinas, E. Moderate alcohol drinking is not associated with risk of depression in older adults 2018 Access copy available to the general public Unrestricted The scarce research on the effects of moderate alcohol consumption on mental health among older adults suggests a protective effect against depression. We prospectively examined the association between patterns of moderate alcohol consumption, depression and psychological distress, using information from 5, 299 community-dwelling older adults from the ELSA and Seniors-ENRICA cohorts. A Mediterranean drinking pattern (MDP) was defined as moderate alcohol intake (<40 g/day for men; <24 g/day for women) with a preference for wine and drinking only with meals. Depression was ascertained with the 10-item Geriatric Depression Scale (GDS-10), a self-report of clinically-diagnosed depression, or being on anti-depressant medication (Seniors-ENRICA); and with the 8-item Center for Epidemiologic Studies Depression Scale (CES-D) (ELSA). Psychological distress was assessed with the General Health Questionnaire-12 (GHQ-12). Compared to never drinkers, moderate drinkers showed comparable scores on the ENRICA-GDS-10 (PRR (95%CI): 1.03 (0.84–1.26)), the ENRICA-GHQ-12 (0.88 (0.73–1.06)), the ELSA-CES-D (0.92 (0.79–1.06)) and the ELSA-GHQ-12 (0.75 (0.55–1.01). The MDP was not associated with the GDS-10 or GHQ-12 scores, or with clinically-diagnosed depression; however drinkers with a preference for wine showed an increased number of psychological distress symptoms (1.31 (1.03–1.66)). In conclusion, we found no consistent protective association between moderate alcohol consumption and depression in older adults. info:eu-repo/grantAgreement/ES/MSCBS/Plan Nacional sobre Drogas 02-2014 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI16-00609 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI12-1166 This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOS info:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOS info:eu-repo/grantAgreement/EC/FP7/305483/EU/Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative/FRAILOMIC info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.011 2018 MULTIDISCIPLINARY SCIENCES 14 / 69 = 0.203 2018 Q1 T1 1.414 2018 Multidisciplinary 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ortolá, R. Galán, I. Soler-Vila, H. (orcid)0000-0003-3963-0846 Laclaustra, M. Rodríguez-Artalejo, F. 8, 1 (2018), 11512 [10 pp] Sci. rep. SCIENTIFIC REPORTS 2045-2322 990449 http://zaguan.unizar.es/record/74954/files/texto_completo.pdf Versión publicada 114306 http://zaguan.unizar.es/record/74954/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:74954 articulos driver 2020-01-17-21:48:01 ARTICLE