000074966 001__ 74966
000074966 005__ 20200117221612.0
000074966 0247_ $$2doi$$a10.1107/S2053230X18004788
000074966 0248_ $$2sideral$$a107609
000074966 037__ $$aART-2018-107609
000074966 041__ $$aeng
000074966 100__ $$aLira-Navarrete, E.
000074966 245__ $$aA perspective on structural and mechanistic aspects of protein O-fucosylation
000074966 260__ $$c2018
000074966 5060_ $$aAccess copy available to the general public$$fUnrestricted
000074966 5203_ $$aProtein O-fucosylation is an important post-translational modification (PTM) found in cysteine-rich repeats in proteins. Protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this PTM and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs), respectively.Within the past six years, crystal structures of both enzymes have been reported, revealing important information on how they recognize protein substrates and achieve catalysis. Here, the structural information available today is summarized and how PoFUT1 and PoFUT2 employ different catalytic mechanisms is discussed.
000074966 536__ $$9info:eu-repo/grantAgreement/EC/FP7/609409/EU/Supporting transnational mobility within the European life sciences by cofunding of the EMBO Fellowship Programme/LTFCOFUND2013$$9info:eu-repo/grantAgreement/ES/DGA/B89
000074966 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000074966 592__ $$a0.701$$b2018
000074966 593__ $$aBiochemistry$$c2018$$dQ2
000074966 593__ $$aBiophysics$$c2018$$dQ2
000074966 593__ $$aStructural Biology$$c2018$$dQ2
000074966 593__ $$aGenetics$$c2018$$dQ2
000074966 593__ $$aMedicine (miscellaneous)$$c2018$$dQ2
000074966 593__ $$aCondensed Matter Physics$$c2018$$dQ2
000074966 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000074966 700__ $$0(orcid)0000-0002-3122-9401$$aHurtado-Guerrero, R.$$uUniversidad de Zaragoza
000074966 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000074966 773__ $$g74, 8 (2018), 443-450$$pActa cryst. F, Struct. biolog. commun.$$tActa Crystallographica Section F-Structural Biology Communications$$x2053-230X
000074966 8564_ $$s559369$$uhttps://zaguan.unizar.es/record/74966/files/texto_completo.pdf$$yVersión publicada
000074966 8564_ $$s98499$$uhttps://zaguan.unizar.es/record/74966/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000074966 909CO $$ooai:zaguan.unizar.es:74966$$particulos$$pdriver
000074966 951__ $$a2020-01-17-21:48:50
000074966 980__ $$aARTICLE