000074967 001__ 74967
000074967 005__ 20210111082904.0
000074967 0247_ $$2doi$$a10.3390/catal8080305
000074967 0248_ $$2sideral$$a107612
000074967 037__ $$aART-2018-107612
000074967 041__ $$aeng
000074967 100__ $$0(orcid)0000-0001-9988-0287$$aGiménez Sonsona, I.
000074967 245__ $$aUrea activation by an external brønsted acid: Breaking self-association and tuning catalytic performance
000074967 260__ $$c2018
000074967 5060_ $$aAccess copy available to the general public$$fUnrestricted
000074967 5203_ $$aIn this work, we hypothesize that Brønsted acids can activate urea-based catalysts by diminishing its self-assembly tendency. As a proof of concept, we used the asymmetric Friedel–Crafts alkylation of indoles with nitroalkenes as a benchmark reaction. The resulting 3-substituted indole derivatives were obtained with better results due to cooperative effects of the chiral urea and a Brønsted acid additive. Such synergy has been rationalized in terms of disassembly of the supramolecular catalyst aggregates, affording a more acidic and rigid catalytic complex.
000074967 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E07-17R$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-88091-P$$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2017-CIE-05
000074967 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000074967 590__ $$a3.444$$b2018
000074967 591__ $$aCHEMISTRY, PHYSICAL$$b57 / 148 = 0.385$$c2018$$dQ2$$eT2
000074967 592__ $$a0.853$$b2018
000074967 593__ $$aPhysical and Theoretical Chemistry$$c2018$$dQ2
000074967 593__ $$aCatalysis$$c2018$$dQ2
000074967 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000074967 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, E.$$uUniversidad de Zaragoza
000074967 700__ $$aHäring, M.
000074967 700__ $$0(orcid)0000-0002-0557-3364$$aDíaz, D.
000074967 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, R.$$uUniversidad de Zaragoza
000074967 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000074967 773__ $$g8, 8 (2018), 305 [21 pp]$$pCatalysts$$tCATALYSTS$$x2073-4344
000074967 8564_ $$s10938078$$uhttps://zaguan.unizar.es/record/74967/files/texto_completo.pdf$$yVersión publicada
000074967 8564_ $$s104637$$uhttps://zaguan.unizar.es/record/74967/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000074967 909CO $$ooai:zaguan.unizar.es:74967$$particulos$$pdriver
000074967 951__ $$a2021-01-11-07:55:19
000074967 980__ $$aARTICLE