000075462 001__ 75462
000075462 005__ 20220908120452.0
000075462 0247_ $$2doi$$a10.3390/ijerph15091836
000075462 0248_ $$2sideral$$a108153
000075462 037__ $$aART-2018-108153
000075462 041__ $$aeng
000075462 100__ $$0(orcid)0000-0001-7587-9716$$aLallana, M.J.
000075462 245__ $$aUse of non-steroidal anti-inflammatory drugs and associated gastroprotection in a cohort of workers
000075462 260__ $$c2018
000075462 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075462 5203_ $$aBackground: This study describes the prevalence of non-steroidal anti-inflammatory drug (NSAID) use, and analyses prescribing patterns of NSAIDs and associated gastroprotection. Methods: The study population consisted of 5650 workers at the General Motors automobile assembly plant in Zaragoza, Spain. NSAID prescription data for 2014 were obtained from the prescription database of Aragon (Spain). NSAID consumption was determined based on the number of defined daily doses purchased per year. Heavy NSAIDs users were identified using Lorenz curves. Results: NSAID use in the cohort was high (40.7% of workers, 95% CI 39.4–41.9). The prescription of proton pump inhibitors increased with age. Gastrointestinal protection was lacking in some participants who were being treated with drugs associated with a high risk of gastrointestinal bleeding. Heavy NSAID users (defined as those above the 95th percentile of consumption), accounted for 26% of total DDDs, and consumed a greater proportion of coxibs than non-heavy users. Conclusions: The rate of NSAID consumption in the cohort was high. To reduce the risk of gastrointestinal complications, monitoring and adequate gastroprotection are essential in patients who are prescribed NSAIDs for long periods of time or who are treated concomitantly with drugs that increase the risk of gastrointestinal bleeding.
000075462 536__ $$9info:eu-repo/grantAgreement/ES/MICINN-ISCIII-FEDER/PI17-011704
000075462 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000075462 590__ $$a2.468$$b2018
000075462 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b38 / 162 = 0.235$$c2018$$dQ1$$eT1
000075462 591__ $$aENVIRONMENTAL SCIENCES$$b112 / 250 = 0.448$$c2018$$dQ2$$eT2
000075462 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b67 / 185 = 0.362$$c2018$$dQ2$$eT2
000075462 592__ $$a0.818$$b2018
000075462 593__ $$aPublic Health, Environmental and Occupational Health$$c2018$$dQ2
000075462 593__ $$aHealth, Toxicology and Mutagenesis$$c2018$$dQ2
000075462 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000075462 700__ $$0(orcid)0000-0002-2712-6709$$aFeja, C.$$uUniversidad de Zaragoza
000075462 700__ $$0(orcid)0000-0001-7293-701X$$aAguilar-Palacio, I.$$uUniversidad de Zaragoza
000075462 700__ $$0(orcid)0000-0002-7194-8275$$aMalo, S.$$uUniversidad de Zaragoza
000075462 700__ $$0(orcid)0000-0002-6671-5661$$aRabanaque, M.J.$$uUniversidad de Zaragoza
000075462 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ.
000075462 773__ $$g15, 9 (2018), 1836 [9 pp]$$pInt. j. environ. res. public health$$tInternational Journal of Environmental Research and Public Health$$x1661-7827
000075462 8564_ $$s492023$$uhttps://zaguan.unizar.es/record/75462/files/texto_completo.pdf$$yVersión publicada
000075462 8564_ $$s114671$$uhttps://zaguan.unizar.es/record/75462/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075462 909CO $$ooai:zaguan.unizar.es:75462$$particulos$$pdriver
000075462 951__ $$a2022-09-08-11:53:55
000075462 980__ $$aARTICLE