75462 20220908120452.0 doi 10.3390/ijerph15091836 sideral 108153 ART-2018-108153 eng Lallana, M.J. (orcid)0000-0001-7587-9716 Use of non-steroidal anti-inflammatory drugs and associated gastroprotection in a cohort of workers 2018 Access copy available to the general public Unrestricted Background: This study describes the prevalence of non-steroidal anti-inflammatory drug (NSAID) use, and analyses prescribing patterns of NSAIDs and associated gastroprotection. Methods: The study population consisted of 5650 workers at the General Motors automobile assembly plant in Zaragoza, Spain. NSAID prescription data for 2014 were obtained from the prescription database of Aragon (Spain). NSAID consumption was determined based on the number of defined daily doses purchased per year. Heavy NSAIDs users were identified using Lorenz curves. Results: NSAID use in the cohort was high (40.7% of workers, 95% CI 39.4–41.9). The prescription of proton pump inhibitors increased with age. Gastrointestinal protection was lacking in some participants who were being treated with drugs associated with a high risk of gastrointestinal bleeding. Heavy NSAID users (defined as those above the 95th percentile of consumption), accounted for 26% of total DDDs, and consumed a greater proportion of coxibs than non-heavy users. Conclusions: The rate of NSAID consumption in the cohort was high. To reduce the risk of gastrointestinal complications, monitoring and adequate gastroprotection are essential in patients who are prescribed NSAIDs for long periods of time or who are treated concomitantly with drugs that increase the risk of gastrointestinal bleeding. info:eu-repo/grantAgreement/ES/MICINN-ISCIII-FEDER/PI17-011704 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.468 2018 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 38 / 162 = 0.235 2018 Q1 T1 ENVIRONMENTAL SCIENCES 112 / 250 = 0.448 2018 Q2 T2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 67 / 185 = 0.362 2018 Q2 T2 0.818 2018 Public Health, Environmental and Occupational Health 2018 Q2 Health, Toxicology and Mutagenesis 2018 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Feja, C. Universidad de Zaragoza (orcid)0000-0002-2712-6709 Aguilar-Palacio, I. Universidad de Zaragoza (orcid)0000-0001-7293-701X Malo, S. Universidad de Zaragoza (orcid)0000-0002-7194-8275 Rabanaque, M.J. Universidad de Zaragoza (orcid)0000-0002-6671-5661 1008 615 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Medic.Prevent.Salud Públ. 15, 9 (2018), 1836 [9 pp] Int. j. environ. res. public health International Journal of Environmental Research and Public Health 1661-7827 492023 http://zaguan.unizar.es/record/75462/files/texto_completo.pdf Versión publicada 114671 http://zaguan.unizar.es/record/75462/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:75462 articulos driver 2022-09-08-11:53:55 ARTICLE