000075480 001__ 75480
000075480 005__ 20200616135723.0
000075480 0247_ $$2doi$$a10.1002/cam4.1719
000075480 0248_ $$2sideral$$a108078
000075480 037__ $$aART-2018-108078
000075480 041__ $$aeng
000075480 100__ $$aHeinrichs, S.K.M.
000075480 245__ $$aEvidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level
000075480 260__ $$c2018
000075480 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075480 5203_ $$aGenetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 × 10-04) and on chromosome 8q24 at rs2585176 (P = 1.09 × 10-09). On chromosome 5p13 we found cis-eQTL effects with an upregulation of PTGER4 expression in GC risk allele carrier (P = 9.27 × 10-11). On chromosome 8q24 we observed cis-eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 × 10-47). In addition, we found trans-eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 × 10-09). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring GC pathomechanisms.
000075480 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00331
000075480 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000075480 590__ $$a3.357$$b2018
000075480 591__ $$aONCOLOGY$$b98 / 229 = 0.428$$c2018$$dQ2$$eT2
000075480 592__ $$a1.425$$b2018
000075480 593__ $$aCancer Research$$c2018$$dQ1
000075480 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2018$$dQ1
000075480 593__ $$aOncology$$c2018$$dQ1
000075480 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000075480 700__ $$aHess, T.
000075480 700__ $$aBecker, J.
000075480 700__ $$aHamann, L.
000075480 700__ $$aVashist, Y.K.
000075480 700__ $$aButterbach, K.
000075480 700__ $$aSchmidt, T.
000075480 700__ $$aAlakus, H.
000075480 700__ $$aKrasniuk, I.
000075480 700__ $$aHöblinger, A.
000075480 700__ $$aLingohr, P.
000075480 700__ $$aLudwig, M.
000075480 700__ $$aHagel, A.F.
000075480 700__ $$aSchildberg, C.W.
000075480 700__ $$aVeits, L.
000075480 700__ $$aGyvyte, U.
000075480 700__ $$aWeise, K.
000075480 700__ $$aSchüller, V.
000075480 700__ $$aBöhmer, A.C.
000075480 700__ $$aSchröder, J.
000075480 700__ $$aGehlen, J.
000075480 700__ $$aKreuser, N.
000075480 700__ $$aHofer, S.
000075480 700__ $$aLang, H.
000075480 700__ $$aLordick, F.
000075480 700__ $$aMalfertheiner, P.
000075480 700__ $$aMoehler, M.
000075480 700__ $$aPech, O.
000075480 700__ $$aVassos, N.
000075480 700__ $$aRodermann, E.
000075480 700__ $$aIzbicki, J.R.
000075480 700__ $$aKruschewski, M.
000075480 700__ $$aOtt, K.
000075480 700__ $$aSchumann, R.R.
000075480 700__ $$aVieth, M.
000075480 700__ $$aMangold, E.
000075480 700__ $$aGasenko, E.
000075480 700__ $$aKupcinskas, L.
000075480 700__ $$aBrenner, H.
000075480 700__ $$aGrimminger, P.
000075480 700__ $$aBujanda, L.
000075480 700__ $$0(orcid)0000-0002-8678-4680$$aSopeña, F.$$uUniversidad de Zaragoza
000075480 700__ $$aEspinel, J.
000075480 700__ $$aThomson, C.
000075480 700__ $$aPérez-Aísa, Á.
000075480 700__ $$aCampo, R.
000075480 700__ $$aGeijo, F.
000075480 700__ $$aCollette, D.
000075480 700__ $$aBruns, C.
000075480 700__ $$aMesserle, K.
000075480 700__ $$aGockel, I.
000075480 700__ $$aNöthen, M.M.
000075480 700__ $$aLippert, H.
000075480 700__ $$aRidwelski, K.
000075480 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, A.$$uUniversidad de Zaragoza
000075480 700__ $$aKeller, G.
000075480 700__ $$aKnapp, M.
000075480 700__ $$aLeja, M.
000075480 700__ $$aKupcinskas, J.
000075480 700__ $$aGarcía-González, M.A.
000075480 700__ $$aVenerito, M.
000075480 700__ $$aSchumacher, J.
000075480 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000075480 773__ $$g7, 10 (2018), 5057 - 5065$$pCancer med.$$tCancer medicine$$x2045-7634
000075480 8564_ $$s417456$$uhttps://zaguan.unizar.es/record/75480/files/texto_completo.pdf$$yVersión publicada
000075480 8564_ $$s99247$$uhttps://zaguan.unizar.es/record/75480/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075480 909CO $$ooai:zaguan.unizar.es:75480$$particulos$$pdriver
000075480 951__ $$a2020-06-16-13:50:53
000075480 980__ $$aARTICLE