000075582 001__ 75582
000075582 005__ 20190709135429.0
000075582 0247_ $$2doi$$a10.1016/j.clnu.2015.11.001
000075582 0248_ $$2sideral$$a99857
000075582 037__ $$aART-2017-99857
000075582 041__ $$aeng
000075582 100__ $$aGuerendiain, M.
000075582 245__ $$aRelation between plasma antioxidant vitamin levels, adiposity and cardio-metabolic profile in adolescents: Effects of a multidisciplinary obesity programme
000075582 260__ $$c2017
000075582 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075582 5203_ $$aBackground & aims
In vivo and in vitro evidence suggests that antioxidant vitamins and carotenoids may be key factors in the treatment and prevention of obesity and obesity-associated disorders. Hence, the objective of the present study was to determine the relationship between plasma lipid-soluble antioxidant vitamin and carotenoid levels and adiposity and cardio-metabolic risk markers in overweight and obese adolescents participating in a multidisciplinary weight loss programme.
Methods
A therapeutic programme was conducted with 103 adolescents aged 12–17 years old and diagnosed with overweight or obesity. Plasma concentrations of a-tocopherol, retinol, ß-carotene and lycopene, anthropometric indicators of general and central adiposity, blood pressure and biochemical parameters were analysed at baseline and at 2 and 6 months of treatment.
Results
Lipid-corrected retinol (P < 0.05), ß-carotene (P = 0.001) and a-tocopherol (P < 0.001) plasma levels increased significantly, whereas lipid-corrected lycopene levels remained unaltered during the treatment. Anthropometric indicators of adiposity (P < 0.001), blood pressure (P < 0.01) and biochemical parameters (P < 0.05) decreased significantly, whereas fat free mass increased significantly (P < 0.001). These clinical and biochemical improvements were related to changes in plasma lipid-corrected antioxidant vitamin and carotenoid levels. The adolescents who experienced the greatest weight loss also showed the largest decrease in anthropometric indicators of adiposity and biochemical parameters and the highest increase in fat free mass. Weight loss in these adolescents was related to an increase in plasma levels of lipid-corrected a-tocopherol (P = 0.001), ß-carotene (P = 0.034) and lycopene (P = 0.019).
Conclusions
Plasma lipid-soluble antioxidant vitamin and carotenoid levels are associated with reduced adiposity, greater weight loss and an improved cardio-metabolic profile in overweight and obese adolescents.
000075582 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/FIS/PI051579
000075582 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000075582 590__ $$a5.496$$b2017
000075582 591__ $$aNUTRITION & DIETETICS$$b8 / 81 = 0.099$$c2017$$dQ1$$eT1
000075582 592__ $$a1.905$$b2017
000075582 593__ $$aNutrition and Dietetics$$c2017$$dQ1
000075582 593__ $$aCritical Care and Intensive Care Medicine$$c2017$$dQ1
000075582 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000075582 700__ $$aMayneris-Perxachs, J.
000075582 700__ $$aMontes, R.
000075582 700__ $$aLópez-Belmonte, G.
000075582 700__ $$aMartín-Matillas, M.
000075582 700__ $$aCastellote, A.I.
000075582 700__ $$aMartín-Bautista, E.
000075582 700__ $$aMartí, A.
000075582 700__ $$aMartínez, J.A.
000075582 700__ $$aMoreno, L.
000075582 700__ $$0(orcid)0000-0002-5165-9716$$aGaragorri, J.M.$$uUniversidad de Zaragoza
000075582 700__ $$aWärnberg, J.
000075582 700__ $$aCaballero, J.
000075582 700__ $$aMarcos, A.
000075582 700__ $$aLópez-Sabater, M.C.
000075582 700__ $$aCampoy, C.
000075582 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Pediatría
000075582 773__ $$g36, 1 (2017), 209-217$$pClin. nutr.$$tClinical Nutrition$$x0261-5614
000075582 8564_ $$s334481$$uhttps://zaguan.unizar.es/record/75582/files/texto_completo.pdf$$yPostprint
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000075582 951__ $$a2019-07-09-11:31:17
000075582 980__ $$aARTICLE