000075651 001__ 75651
000075651 005__ 20240111111736.0
000075651 0247_ $$2doi$$a10.1016/j.numecd.2017.10.024
000075651 0248_ $$2sideral$$a104940
000075651 037__ $$aART-2018-104940
000075651 041__ $$aeng
000075651 100__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, R.$$uUniversidad de Zaragoza
000075651 245__ $$aDifferent protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women
000075651 260__ $$c2018
000075651 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075651 5203_ $$aBackground and aims: High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; similar to 80% coming from animal source) on plasma adipokine concentration and its association with changes in cardiometabolic markers. 
Methods: Seventy-six women (BMI 32.8 +/- 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months. Plasma adipokine (leptin, resistin, adiponectin, and retinol-binding protein 4; RBP4) levels were assessed. 
Results: After 3 months, leptin concentration decreased in all groups without differences among them, while resistin levels remained unchanged. Adiponectin concentration heterogeneously changed in all groups (P for trend = 0.165) and resistin concentration did not significantly change. RPB4 significantly decreased by -17.5% (-31.7, -3.22) in 35%-protein diet (P for trend = 0.024 among diets). Triglycerides improved in women following the 35%-protein diet regardless of weight loss; RBP4 variation significantly influenced triglyceride concentration change by 24.9% and 25.9% when comparing 27%- and 35%- with 20%-protein diet, respectively. 
Conclusions: A 35%-protein diet induced a decrease in RBP4 regardless of weight loss, which was directly associated with triglyceride concentration improvement. These findings suggest that HP diets improve the cardiometabolic profile, at least in part, through changes in adipokine secretion. Whether this beneficial effect of HP diet is due to improvements in hepatic or adipose tissue functionality should be elucidated.
000075651 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02507$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983
000075651 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000075651 590__ $$a3.34$$b2018
000075651 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b50 / 135 = 0.37$$c2018$$dQ2$$eT2
000075651 591__ $$aNUTRITION & DIETETICS$$b33 / 85 = 0.388$$c2018$$dQ2$$eT2
000075651 591__ $$aENDOCRINOLOGY & METABOLISM$$b59 / 145 = 0.407$$c2018$$dQ2$$eT2
000075651 592__ $$a1.318$$b2018
000075651 593__ $$aCardiology and Cardiovascular Medicine$$c2018$$dQ1
000075651 593__ $$aNutrition and Dietetics$$c2018$$dQ1
000075651 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000075651 593__ $$aEndocrinology, Diabetes and Metabolism$$c2018$$dQ1
000075651 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000075651 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, I.
000075651 700__ $$0(orcid)0000-0002-1894-1621$$aPerez-Calahorra, S.
000075651 700__ $$aMarco-Benedi, V.
000075651 700__ $$aBea, A.M.
000075651 700__ $$aBaila-Rueda, L.
000075651 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.
000075651 700__ $$aPenalvo, J.L.
000075651 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000075651 700__ $$aCenarro, A.
000075651 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000075651 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000075651 773__ $$g28, 2 (2018), 133-142$$pNMCD, Nutr. Metab. Cardiovasc. Dis.$$tNutrition, Metabolism and Cardiovascular Diseases$$x0939-4753
000075651 8564_ $$s348478$$uhttps://zaguan.unizar.es/record/75651/files/texto_completo.pdf$$yPostprint
000075651 8564_ $$s106730$$uhttps://zaguan.unizar.es/record/75651/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000075651 909CO $$ooai:zaguan.unizar.es:75651$$particulos$$pdriver
000075651 951__ $$a2024-01-11-10:59:01
000075651 980__ $$aARTICLE