75651 20240111111736.0 doi 10.1016/j.numecd.2017.10.024 sideral 104940 ART-2018-104940 eng Mateo-Gallego, R. Universidad de Zaragoza (orcid)0000-0001-6650-8294 Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women 2018 Access copy available to the general public Unrestricted Background and aims: High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; similar to 80% coming from animal source) on plasma adipokine concentration and its association with changes in cardiometabolic markers. Methods: Seventy-six women (BMI 32.8 +/- 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months. Plasma adipokine (leptin, resistin, adiponectin, and retinol-binding protein 4; RBP4) levels were assessed. Results: After 3 months, leptin concentration decreased in all groups without differences among them, while resistin levels remained unchanged. Adiponectin concentration heterogeneously changed in all groups (P for trend = 0.165) and resistin concentration did not significantly change. RPB4 significantly decreased by -17.5% (-31.7, -3.22) in 35%-protein diet (P for trend = 0.024 among diets). Triglycerides improved in women following the 35%-protein diet regardless of weight loss; RBP4 variation significantly influenced triglyceride concentration change by 24.9% and 25.9% when comparing 27%- and 35%- with 20%-protein diet, respectively. Conclusions: A 35%-protein diet induced a decrease in RBP4 regardless of weight loss, which was directly associated with triglyceride concentration improvement. These findings suggest that HP diets improve the cardiometabolic profile, at least in part, through changes in adipokine secretion. Whether this beneficial effect of HP diet is due to improvements in hepatic or adipose tissue functionality should be elucidated. info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02507 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.34 2018 CARDIAC & CARDIOVASCULAR SYSTEMS 50 / 135 = 0.37 2018 Q2 T2 NUTRITION & DIETETICS 33 / 85 = 0.388 2018 Q2 T2 ENDOCRINOLOGY & METABOLISM 59 / 145 = 0.407 2018 Q2 T2 1.318 2018 Cardiology and Cardiovascular Medicine 2018 Q1 Nutrition and Dietetics 2018 Q1 Medicine (miscellaneous) 2018 Q1 Endocrinology, Diabetes and Metabolism 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Lamiquiz-Moneo, I. (orcid)0000-0002-9647-0108 Perez-Calahorra, S. (orcid)0000-0002-1894-1621 Marco-Benedi, V. Bea, A.M. Baila-Rueda, L. Laclaustra, M. (orcid)0000-0003-3963-0846 Penalvo, J.L. Civeira, F. Universidad de Zaragoza (orcid)0000-0001-7043-0952 Cenarro, A. 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 28, 2 (2018), 133-142 NMCD, Nutr. Metab. Cardiovasc. Dis. Nutrition, Metabolism and Cardiovascular Diseases 0939-4753 348478 http://zaguan.unizar.es/record/75651/files/texto_completo.pdf Postprint 106730 http://zaguan.unizar.es/record/75651/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:75651 articulos driver 2024-01-11-10:59:01 ARTICLE