In-vivo cell remote control: a mecano-electro computational study

Doweidar, M.H. (Universidad de Zaragoza) ; Mousavi, S.J.

Resumen: Abstract ICBB17-12:
Nowadays, due to its importance for human survival, tissue andorgans regeneration have received a high attention of the scientificcommunity. For the development of this field, understanding the cellbehavior is essential forin-vivotissue and organs regeneration. Cellbehavior can be controlledin-vitro, among other stimuli, by changingthe extracellular matrix mechanical properties, applying externalforces and/or electrical field. Controlling these stimuliin-vivois nottrivial. Therefore, in this work, to remotely control the local cellenvironment, we consider a microsphere of cell size that is fabricatedfrom a piezoelectric material and charged with nanomagnetic parti-cles. This microsphere is integrated within an extracellular matrix, insuch a way, through an external magnetic field, internal forces canbe generated within the microsphere. As a result, a stiffness gradientas well as an electric field are generated around the microsphere.These cues can be controlled externally by changing the magneticfield intensity...

Idioma: Inglés

Año: 2018

Publicado en: Basic & clinical pharmacology & toxicology 122, Supp. 1 (2018), 6
ISSN: 1742-7835

Originalmente disponible en: Texto completo de la revista

Factor impacto JCR: 2.452 (2018)

Categ. JCR: TOXICOLOGY rank: 53 / 93 = 0.57 (2018) - Q3 - T2
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 140 / 266 = 0.526 (2018) - Q3 - T2

Factor impacto SCIMAGO: 0.728 - Medicine (miscellaneous) (Q2) - Toxicology (Q2) - Pharmacology (Q2)

Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2016-76039-C4-4-R

Tipo y forma: Comunicación congreso (Versión definitiva)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)