000075682 001__ 75682
000075682 005__ 20200113145618.0
000075682 0247_ $$2doi$$a10.1002/anie.201800288
000075682 0248_ $$2sideral$$a106543
000075682 037__ $$aART-2018-106543
000075682 041__ $$aeng
000075682 100__ $$aAlonso de Castro, S.
000075682 245__ $$aBioorthogonal catalytic activation of Platinum and Ruthenium anticancer complexes by FAD and flavoproteins
000075682 260__ $$c2018
000075682 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075682 5203_ $$aRecent advances in bioorthogonal catalysis promise to deliver new chemical tools for performing chemoselective transformations in complex biological environments. Herein, we report how FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), and four flavoproteins act as unconventional photocatalysts capable of converting PtIV and RuII complexes into potentially toxic PtII or RuII-OH2 species. In the presence of electron donors and low doses of visible light, the flavoproteins mini singlet oxygen generator (miniSOG) and NADH oxidase (NOX) catalytically activate PtIV prodrugs with bioorthogonal selectivity. In the presence of NADH, NOX catalyzes PtIV activation in the dark as well, indicating for the first time that flavoenzymes may contribute to initiating the activity of PtIV chemotherapeutic agents.
000075682 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-80844-R$$9info:eu-repo/grantAgreement/ES/MINECO/BIO2016-77367-C2-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/BIO2015-69887-R$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2013-065642$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 648071-ProNANO$$9info:eu-repo/grantAgreement/EC/H2020/648071/EU/Protein-based functional nanostructures/ProNANO$$9info:eu-repo/grantAgreement/EUR/COST/CM1303
000075682 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000075682 590__ $$a12.257$$b2018
000075682 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b17 / 172 = 0.099$$c2018$$dQ1$$eT1
000075682 592__ $$a5.478$$b2018
000075682 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1
000075682 593__ $$aCatalysis$$c2018$$dQ1
000075682 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000075682 700__ $$aCortajarena, A.L.
000075682 700__ $$0(orcid)0000-0003-0031-1880$$aLópez-Gallego, F.$$uUniversidad de Zaragoza
000075682 700__ $$aSalassa, L.
000075682 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000075682 773__ $$g57, 12 (2018), 3143-3147$$pAngew. Chem. (Int. ed.)$$tAngewandte Chemie (International ed.)$$x1433-7851
000075682 8564_ $$s2747786$$uhttps://zaguan.unizar.es/record/75682/files/texto_completo.pdf$$yVersión publicada
000075682 8564_ $$s136390$$uhttps://zaguan.unizar.es/record/75682/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075682 909CO $$ooai:zaguan.unizar.es:75682$$particulos$$pdriver
000075682 951__ $$a2020-01-13-14:54:20
000075682 980__ $$aARTICLE