000075688 001__ 75688
000075688 005__ 20190709135646.0
000075688 0247_ $$2doi$$a10.1038/ijo.2017.132
000075688 0248_ $$2sideral$$a105512
000075688 037__ $$aART-2017-105512
000075688 041__ $$aeng
000075688 100__ $$aSanchez, J.
000075688 245__ $$aTranscriptome analysis in blood cells from children reveals potential early biomarkers of metabolic alterations
000075688 260__ $$c2017
000075688 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075688 5203_ $$aOBJECTIVES: The development of effective strategies to prevent childhood obesity and its comorbidities requires new, reliable early biomarkers. Here, we aimed to identify in peripheral blood cells potential transcript-based biomarkers of unhealthy metabolic profile associated to overweight/obesity in children.
METHODS: We performed a whole-genome microarray analysis in blood cells to identify genes differentially expressed between overweight and normal weight children to obtain novel transcript-based biomarkers predictive of metabolic complications.
RESULTS: The most significant enriched pathway of differentially expressed genes was related to oxidative phosphorylation, for which most of genes were downregulated in overweight versus normal weight children. Other genes were involved in carbohydrate metabolism/glucose homoeostasis or in lipid metabolism (for example, TCF7L2, ADRB3, LIPE, GIPR), revealing plausible mechanisms according to existing biological knowledge. A set of differentially expressed genes was identified to discriminate in overweight children those with high or low triglyceride levels.
CONCLUSIONS: Functional microarray analysis has revealed a set of potential blood-cell transcript-based biomarkers that may be a useful approach for early identification of children with higher predisposition to obesity-related metabolic alterations.
000075688 536__ $$9info:eu-repo/grantAgreement/EC/FP7/266044/EU/Determinants of eating behaviour in European children, adolescents and their parents/I.FAMILY$$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181
000075688 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000075688 590__ $$a5.151$$b2017
000075688 591__ $$aNUTRITION & DIETETICS$$b10 / 81 = 0.123$$c2017$$dQ1$$eT1
000075688 591__ $$aENDOCRINOLOGY & METABOLISM$$b23 / 143 = 0.161$$c2017$$dQ1$$eT1
000075688 592__ $$a2.65$$b2017
000075688 593__ $$aEndocrinology, Diabetes and Metabolism$$c2017$$dQ1
000075688 593__ $$aNutrition and Dietetics$$c2017$$dQ1
000075688 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000075688 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000075688 700__ $$aPico, C.
000075688 700__ $$aAhrens, W.
000075688 700__ $$aForaita, R.
000075688 700__ $$aFraterman, A.
000075688 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000075688 700__ $$aRusso, P.
000075688 700__ $$aSiani, A.
000075688 700__ $$aPalou, A.
000075688 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000075688 773__ $$g41, 10 (2017), 1481-1488$$pInt. j. obes.$$tINTERNATIONAL JOURNAL OF OBESITY$$x0307-0565
000075688 8564_ $$s710992$$uhttps://zaguan.unizar.es/record/75688/files/texto_completo.pdf$$yPostprint
000075688 8564_ $$s56362$$uhttps://zaguan.unizar.es/record/75688/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000075688 909CO $$ooai:zaguan.unizar.es:75688$$particulos$$pdriver
000075688 951__ $$a2019-07-09-12:41:06
000075688 980__ $$aARTICLE