000075705 001__ 75705
000075705 005__ 20190709135701.0
000075705 0247_ $$2doi$$a10.2217/nnm-2017-0198
000075705 0248_ $$2sideral$$a103538
000075705 037__ $$aART-2017-103538
000075705 041__ $$aeng
000075705 100__ $$aSchwinté, P.
000075705 245__ $$aAnti-inflammatory effect of active nanofibrous polymeric membrane bearing nanocontainers of atorvastatin complexes
000075705 260__ $$c2017
000075705 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075705 5203_ $$aAim: We developed polymeric membranes for local administration of nonsoluble anti-inflammatory statin, as potential wound patch in rheumatic joint or periodontal lesions. Methods: Electrospun polycaprolactone membranes were fitted with polysaccharide-atorvastatin nanoreservoirs by using complexes with poly-aminocyclodextrin. Characterization methods are UV-Visible and X-ray photoelectron spectroscopy, molecular dynamics, scanning and transmission electron microscopy. In vitro, membranes were seeded with macrophages, and inflammatory cytokine expression were monitored. Results & conclusion: Stable inclusion complexes were formed in solution (1:1 stability constant 368 M- 1, -117.40 kJ mol- 1), with supramolecular globular organization (100 nm, substructure 30 nm). Nanoreservoir technology leads to homogeneous distribution of atorvastatin calcium trihydrate complexes in the membrane. Quantity embedded was estimated (70-90 µg in 30 µm × 6 mm membrane). Anti-inflammatory effect by cell contact-dependent release reached 60% inhibition for TNF-a and 80% for IL-6. The novelty resides in the double protection offered by the cyclodextrins as drug molecular chaperones, with further embedding into biodegradable nanoreservoirs. The strategy is versatile and can target other diseases.
000075705 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000075705 590__ $$a5.005$$b2017
000075705 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b22 / 160 = 0.138$$c2017$$dQ1$$eT1
000075705 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b32 / 92 = 0.348$$c2017$$dQ2$$eT2
000075705 592__ $$a1.302$$b2017
000075705 593__ $$aBioengineering$$c2017$$dQ1
000075705 593__ $$aBiomedical Engineering$$c2017$$dQ1
000075705 593__ $$aDevelopment$$c2017$$dQ1
000075705 593__ $$aMaterials Science (miscellaneous)$$c2017$$dQ1
000075705 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000075705 593__ $$aNanoscience and Nanotechnology$$c2017$$dQ2
000075705 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000075705 700__ $$aMariotte, A.
000075705 700__ $$aAnand, P.
000075705 700__ $$aKeller, L.
000075705 700__ $$aIdoux-Gillet, Y.
000075705 700__ $$aHuck, O.
000075705 700__ $$aFioretti, F.
000075705 700__ $$aTenenbaum, H.
000075705 700__ $$aGeorgel, P.
000075705 700__ $$aWenzel, W.
000075705 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000075705 700__ $$aBenkirane-Jessel, N.
000075705 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000075705 773__ $$g12, 23 (2017), 2651-2674$$pNanomedicine$$tNanomedicine$$x1743-5889
000075705 8564_ $$s2114744$$uhttps://zaguan.unizar.es/record/75705/files/texto_completo.pdf$$yPostprint
000075705 8564_ $$s35820$$uhttps://zaguan.unizar.es/record/75705/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000075705 909CO $$ooai:zaguan.unizar.es:75705$$particulos$$pdriver
000075705 951__ $$a2019-07-09-12:49:12
000075705 980__ $$aARTICLE