75735 20200729203741.0 doi 10.1080/02713683.2017.1387272 sideral 103914 ART-2017-103914 eng (orcid)0000-0002-6134-8698 Sierra, M. Universidad de Zaragoza Effect of cryopreserved amniotic membrane on the mechanical properties of skeletal muscle after strabismus surgery in rabbits 2017 Access copy available to the general public Unrestricted Purpose: To study the functional recovery of the superior rectus muscle (SRM) after its partial resection in a rabbit model with and without cryopreserved amniotic membrane (AM). Material and methods: Resection of the right and left SRMs of 30 rabbits was performed. On the left eyes, a single sheet of equine cryopreserved AM was placed covering the muscle edge sutured. Active and passive mechanical properties of muscles operated with and without AM were monitored over time at 30 (n = 10), 60 (n = 10), and 90 (n = 10) days after surgery. Muscle samples were extracted and electrically stimulated to register the force exerted by the samples, characterizing its active behavior. They were, then, subjected to stretching test to obtain its resistance to deformation, known as passive behavior. Moreover, right and left eyes of a control group (n = 5) were equally subjected to active and passive tests to characterize the physiological behavior of SRM muscles. Results: On active function examination, statistically significant differences were documented between the following: control vs AM and no AM at 30 days (p = 0.002 and p = 0.04, respectively). All other comparisons were insignificant (p > 0.05). On passive function analysis, significant differences were only found between control vs. no AM at 30 days (p = 0.004) and between AM vs. no AM at 30 days (p = 0.002). Indeed, muscle operated without AM did not recover a normal passive function until 60 days after surgery. Conclusion: Cryopreserved AM is effective in accelerating recovery of SRM passive function in rabbits. Nevertheless, AM produced no significant effect on recovery of SRM active function.¿ info:eu-repo/grantAgreement/ES/DGA/T88 info:eu-repo/grantAgreement/ES/MINECO/DPI2014-54981-R info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84047-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.12 2017 OPHTHALMOLOGY 27 / 59 = 0.458 2017 Q2 T2 0.956 2017 Ophthalmology 2017 Q2 Sensory Systems 2017 Q3 Cellular and Molecular Neuroscience 2017 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0003-2770-4617 Ortillés, A. Universidad de Zaragoza (orcid)0000-0001-5981-5448 Miana-Mena, F.J. Universidad de Zaragoza (orcid)0000-0002-6870-0594 Grasa, J. Universidad de Zaragoza (orcid)0000-0001-9713-1813 Calvo, B. Universidad de Zaragoza 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 1005 315 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Farmacología 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 43, 2 (2017), 193-199 Curr. eye res. CURRENT EYE RESEARCH 0271-3683 313412 http://zaguan.unizar.es/record/75735/files/texto_completo.pdf Postprint 29591 http://zaguan.unizar.es/record/75735/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:75735 articulos driver 2020-07-29-20:20:07 ARTICLE