000075761 001__ 75761 000075761 005__ 20201216081411.0 000075761 0247_ $$2doi$$a10.1016/j.phytol.2016.11.005 000075761 0248_ $$2sideral$$a97061 000075761 037__ $$aART-2017-97061 000075761 041__ $$aeng 000075761 100__ $$0(orcid)0000-0003-2713-2786$$aMartín-Ramos, P.$$uUniversidad de Zaragoza 000075761 245__ $$aOn the probable composition of ‘Jamaican stone’ aphrodisiac 000075761 260__ $$c2017 000075761 5060_ $$aAccess copy available to the general public$$fUnrestricted 000075761 5203_ $$aA dangerous aphrodisiac, commonly known as ‘Jamaican stone’, banned by the U.S. Food and Drug Administration, has been studied by vibrational spectroscopy in order to solve the controversy on its composition. The results of the ATR-FTIR analysis revealed the presence of the a-pyrone ring, which is characteristic of bufadienolides from toad venom and bulbs of squill (Drimia maritima (L.) Stearn). This conclusion was reached after a comparative study with the spectra for phytochemicals derived from gambir and cat''s claw, two Uncaria species also preconized as aphrodisiacs and deemed as possible constituents of the ‘stone’. Owing to their physiologic similarities to digoxin, bufadienolides have been shown to produce a toxic profile similar to that of digoxin, although the lack one of the side chains found on digoxin should allow the use of hemodialysis to treat ‘Jamaican stone’ overdose. 000075761 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000075761 590__ $$a1.575$$b2017 000075761 591__ $$aPLANT SCIENCES$$b95 / 222 = 0.428$$c2017$$dQ2$$eT2 000075761 591__ $$aCHEMISTRY, MEDICINAL$$b48 / 59 = 0.814$$c2017$$dQ4$$eT3 000075761 592__ $$a0.634$$b2017 000075761 593__ $$aAgronomy and Crop Science$$c2017$$dQ1 000075761 593__ $$aPlant Science$$c2017$$dQ2 000075761 593__ $$aBiotechnology$$c2017$$dQ2 000075761 593__ $$aBiochemistry$$c2017$$dQ3 000075761 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000075761 700__ $$aCarrión-Prieto, P. 000075761 700__ $$aSilva-Castro, I. 000075761 700__ $$aRuiz-Potosme, N. 000075761 700__ $$aHernández-Navarro, S. 000075761 700__ $$aMartín-Gil, J. 000075761 7102_ $$15011$$2500$$aUniversidad de Zaragoza$$bDpto. CC.Agrar.y Medio Natural$$cArea Ingeniería Agroforestal 000075761 773__ $$g19 (2017), 30-33$$pPhytochemistry Letters$$tPhytochemistry Letters$$x1874-3900 000075761 8564_ $$s151278$$uhttps://zaguan.unizar.es/record/75761/files/texto_completo.pdf$$yPostprint 000075761 8564_ $$s105001$$uhttps://zaguan.unizar.es/record/75761/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000075761 909CO $$ooai:zaguan.unizar.es:75761$$particulos$$pdriver 000075761 951__ $$a2020-12-16-08:09:39 000075761 980__ $$aARTICLE