000075770 001__ 75770
000075770 005__ 20190709135622.0
000075770 0247_ $$2doi$$a10.1088/1361-6560/aa9536
000075770 0248_ $$2sideral$$a104310
000075770 037__ $$aART-2017-104310
000075770 041__ $$aeng
000075770 100__ $$aManeru, F.
000075770 245__ $$aDosimetry and prescription in liver radioembolization with 90Y microspheres: 3D calculation of tumor-to-liver ratio from global 99mTc-MAA SPECT information
000075770 260__ $$c2017
000075770 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075770 5203_ $$aDosimetry in liver radioembolization with 90Y microspheres is a fundamental tool, both for the optimization of each treatment and for improving knowledge of the treatment effects in the tissues. Different options are available for estimating the administered activity and the tumor/organ dose, among them the so-called partition method. The key factor in the partition method is the tumor/normal tissue activity uptake ratio (T/N), which is obtained by a single-photon emission computed tomography (SPECT) scan during a pre-treatment simulation. The less clear the distinction between healthy and tumor parenchyma within the liver, the more difficult it becomes to estimate the T/N ratio; therefore the use of the method is limited. This study presents a methodology to calculate the T/N ratio using global information from the SPECT. The T/N ratio is estimated by establishing uptake thresholds consistent with previously performed volumetry. This dose calculation method was validated against 3D voxel dosimetry, and was also compared with the standard partition method based on freehand regions of interest (ROI) outlining on SPECT slices. Both comparisons were done on a sample of 20 actual cases of hepatocellular carcinoma treated with resin microspheres. The proposed method and the voxel dosimetry method yield similar results, while the ROI-based method tends to over-estimate the dose to normal tissues. In addition, the variability associated with the ROI-based method is more extreme than the other methods. The proposed method is simpler than either the ROI or voxel dosimetry approaches and avoids the subjectivity associated with the manual selection of regions.
000075770 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000075770 590__ $$a2.665$$b2017
000075770 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b42 / 127 = 0.331$$c2017$$dQ2$$eT2
000075770 591__ $$aENGINEERING, BIOMEDICAL$$b27 / 78 = 0.346$$c2017$$dQ2$$eT2
000075770 592__ $$a1.263$$b2017
000075770 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2017$$dQ1
000075770 593__ $$aRadiological and Ultrasound Technology$$c2017$$dQ1
000075770 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000075770 700__ $$0(orcid)0000-0002-5512-5885$$aAbós, D.$$uUniversidad de Zaragoza
000075770 700__ $$aBragado, L.
000075770 700__ $$aFuentemilla, N.
000075770 700__ $$aCaudepón, F.
000075770 700__ $$aPellejero, S.
000075770 700__ $$aMiquelez, S.
000075770 700__ $$aRubio, A.
000075770 700__ $$aGoni, E.
000075770 700__ $$0(orcid)0000-0002-4188-4151$$aHernández-Vitoria, A.$$uUniversidad de Zaragoza
000075770 7102_ $$11010$$2770$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Radiol. y Medicina Física
000075770 773__ $$g62, 23 (2017), 9099-9111$$pPhys. med. biol.$$tPhysics in Medicine and Biology$$x0031-9155
000075770 8564_ $$s467596$$uhttps://zaguan.unizar.es/record/75770/files/texto_completo.pdf$$yPostprint
000075770 8564_ $$s46255$$uhttps://zaguan.unizar.es/record/75770/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000075770 909CO $$ooai:zaguan.unizar.es:75770$$particulos$$pdriver
000075770 951__ $$a2019-07-09-12:28:25
000075770 980__ $$aARTICLE