000075779 001__ 75779
000075779 005__ 20210111082902.0
000075779 0247_ $$2doi$$a10.3390/molecules23102692
000075779 0248_ $$2sideral$$a108766
000075779 037__ $$aART-2018-108766
000075779 041__ $$aeng
000075779 100__ $$0(orcid)0000-0002-3726-0493$$aAuria-Luna, F.
000075779 245__ $$aFirst organocatalytic asymmetric synthesis of 1-Benzamido-1, 4-Dihydropyridine Derivatives
000075779 260__ $$c2018
000075779 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075779 5203_ $$aPreliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1, 4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of ß-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40-54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1, 4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1, 4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.
000075779 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E07-17R$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-88091-P$$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2017-CIE-05
000075779 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000075779 590__ $$a3.06$$b2018
000075779 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b67 / 172 = 0.39$$c2018$$dQ2$$eT2
000075779 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b133 / 294 = 0.452$$c2018$$dQ2$$eT2
000075779 592__ $$a0.757$$b2018
000075779 593__ $$aAnalytical Chemistry$$c2018$$dQ1
000075779 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1
000075779 593__ $$aDrug Discovery$$c2018$$dQ1
000075779 593__ $$aPhysical and Theoretical Chemistry$$c2018$$dQ1
000075779 593__ $$aMolecular Medicine$$c2018$$dQ1
000075779 593__ $$aOrganic Chemistry$$c2018$$dQ1
000075779 593__ $$aPharmaceutical Science$$c2018$$dQ1
000075779 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000075779 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000075779 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, E.$$uUniversidad de Zaragoza
000075779 700__ $$0(orcid)0000-0002-5244-9569$$aPerez Herrera, R.$$uUniversidad de Zaragoza
000075779 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000075779 773__ $$g23, 10 (2018), 2692$$pMolecules$$tMolecules$$x1420-3049
000075779 8564_ $$s664487$$uhttps://zaguan.unizar.es/record/75779/files/texto_completo.pdf$$yVersión publicada
000075779 8564_ $$s118059$$uhttps://zaguan.unizar.es/record/75779/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075779 909CO $$ooai:zaguan.unizar.es:75779$$particulos$$pdriver
000075779 951__ $$a2021-01-11-07:55:11
000075779 980__ $$aARTICLE