doi:10.3390/molecules23102692engAuria-Luna, F.Marqués-López, E.Perez Herrera, R.First organocatalytic asymmetric synthesis of 1-Benzamido-1, 4-Dihydropyridine DerivativesART-2018-108766Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1, 4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of ß-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40-54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1, 4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1, 4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.2018http://zaguan.unizar.es/record/7577910.3390/molecules23102692http://zaguan.unizar.es/record/75779oai:zaguan.unizar.es:75779info:eu-repo/grantAgreement/ES/DGA/E07-17Rinfo:eu-repo/grantAgreement/ES/MINECO/CTQ2017-88091-Pinfo:eu-repo/grantAgreement/ES/UZ/JIUZ-2017-CIE-05Molecules 23, 10 (2018), 2692byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess