75779 20210111082902.0 doi 10.3390/molecules23102692 sideral 108766 ART-2018-108766 eng (orcid)0000-0002-3726-0493 Auria-Luna, F. First organocatalytic asymmetric synthesis of 1-Benzamido-1, 4-Dihydropyridine Derivatives 2018 Access copy available to the general public Unrestricted Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1, 4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of ß-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40-54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1, 4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1, 4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored. info:eu-repo/grantAgreement/ES/DGA/E07-17R info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-88091-P info:eu-repo/grantAgreement/ES/UZ/JIUZ-2017-CIE-05 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.06 2018 CHEMISTRY, MULTIDISCIPLINARY 67 / 172 = 0.39 2018 Q2 T2 BIOCHEMISTRY & MOLECULAR BIOLOGY 133 / 294 = 0.452 2018 Q2 T2 0.757 2018 Analytical Chemistry 2018 Q1 Chemistry (miscellaneous) 2018 Q1 Drug Discovery 2018 Q1 Physical and Theoretical Chemistry 2018 Q1 Molecular Medicine 2018 Q1 Organic Chemistry 2018 Q1 Pharmaceutical Science 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-6832-8983 Marqués-López, E. Universidad de Zaragoza (orcid)0000-0002-5244-9569 Perez Herrera, R. Universidad de Zaragoza 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 23, 10 (2018), 2692 Molecules Molecules 1420-3049 664487 http://zaguan.unizar.es/record/75779/files/texto_completo.pdf Versión publicada 118059 http://zaguan.unizar.es/record/75779/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:75779 articulos driver 2021-01-11-07:55:11 ARTICLE