000075782 001__ 75782
000075782 005__ 20191212102142.0
000075782 0247_ $$2doi$$a10.3390/ijerph15102241
000075782 0248_ $$2sideral$$a108770
000075782 037__ $$aART-2018-108770
000075782 041__ $$aeng
000075782 100__ $$aPilz, S.
000075782 245__ $$aThe role of vitamin D in fertility and during pregnancy and lactation: A review of clinical data
000075782 260__ $$c2018
000075782 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075782 5203_ $$aVitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.
000075782 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000075782 590__ $$a2.468$$b2018
000075782 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b38 / 162 = 0.235$$c2018$$dQ1$$eT1
000075782 591__ $$aENVIRONMENTAL SCIENCES$$b112 / 250 = 0.448$$c2018$$dQ2$$eT2
000075782 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b67 / 185 = 0.362$$c2018$$dQ2$$eT2
000075782 592__ $$a0.818$$b2018
000075782 593__ $$aPublic Health, Environmental and Occupational Health$$c2018$$dQ2
000075782 593__ $$aHealth, Toxicology and Mutagenesis$$c2018$$dQ2
000075782 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000075782 700__ $$aZittermann, A.
000075782 700__ $$aObeid, R.
000075782 700__ $$aHahn, A.
000075782 700__ $$aPludowski, P.
000075782 700__ $$aTrummer, C.
000075782 700__ $$aLerchbaum, E.
000075782 700__ $$0(orcid)0000-0002-2801-416X$$aPérez-López, F.R.$$uUniversidad de Zaragoza
000075782 700__ $$aKarras, S.N.
000075782 700__ $$aMärz, W.
000075782 7102_ $$11004$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Obstetricia y Ginecología
000075782 773__ $$g15, 10 (2018), 2241 [19 pp]$$pInt. j. environ. res. public health$$tInternational Journal of Environmental Research and Public Health$$x1661-7827
000075782 8564_ $$s348883$$uhttps://zaguan.unizar.es/record/75782/files/texto_completo.pdf$$yVersión publicada
000075782 8564_ $$s112266$$uhttps://zaguan.unizar.es/record/75782/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075782 909CO $$ooai:zaguan.unizar.es:75782$$particulos$$pdriver
000075782 951__ $$a2019-12-12-10:13:06
000075782 980__ $$aARTICLE