The role of vitamin D in fertility and during pregnancy and lactation: A review of clinical data
Resumen: Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.
Idioma: Inglés
DOI: 10.3390/ijerph15102241
Año: 2018
Publicado en: International Journal of Environmental Research and Public Health 15, 10 (2018), 2241 [19 pp]
ISSN: 1661-7827

Factor impacto JCR: 2.468 (2018)
Categ. JCR: PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH rank: 38 / 162 = 0.235 (2018) - Q1 - T1
Categ. JCR: ENVIRONMENTAL SCIENCES rank: 112 / 250 = 0.448 (2018) - Q2 - T2
Categ. JCR: PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH rank: 67 / 185 = 0.362 (2018) - Q2 - T2

Factor impacto SCIMAGO: 0.818 - Public Health, Environmental and Occupational Health (Q2) - Health, Toxicology and Mutagenesis (Q2)

Tipo y forma: Review (Published version)
Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía,Ginecol.Obstetr.)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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Articles > Artículos por área > Obstetricia y Ginecología



 Record created 2018-11-23, last modified 2019-12-12


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