000075865 001__ 75865 000075865 005__ 20200117212657.0 000075865 0247_ $$2doi$$a10.1016/j.bpj.2018.10.009 000075865 0248_ $$2sideral$$a108823 000075865 037__ $$aART-2018-108823 000075865 041__ $$aeng 000075865 100__ $$aRaffa, V. 000075865 245__ $$aPiconewton Mechanical Forces Promote Neurite Growth 000075865 260__ $$c2018 000075865 5060_ $$aAccess copy available to the general public$$fUnrestricted 000075865 5203_ $$aInvestigations over half a century have indicated that mechanical forces induce neurite growth, with neurites elongating at a rate of 0.1–0.3 µm h-1 pN-1 when mechanical force exceeds a threshold, with this being identified as 400–1000 pN for neurites of PC12 cells. In this article, we demonstrate that neurite elongation of PC12 cells proceeds at the same previously identified rate on application of mechanical tension of ~1 pN, which is significantly lower than the force generated in vivo by axons and growth cones. This observation raises the possibility that mechanical tension may act as an endogenous signal used by neurons for promoting neurite elongation. 000075865 536__ $$9info:eu-repo/grantAgreement/EC/FP7/622122/EU/Magnetically Enhanced Controlled Axonal Regeneration/MECAR 000075865 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000075865 590__ $$a3.665$$b2018 000075865 591__ $$aBIOPHYSICS$$b20 / 72 = 0.278$$c2018$$dQ2$$eT1 000075865 592__ $$a2.018$$b2018 000075865 593__ $$aBiophysics$$c2018$$dQ1 000075865 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000075865 700__ $$aFalcone, F. 000075865 700__ $$aDe Vincentiis, S. 000075865 700__ $$aFalconieri, A. 000075865 700__ $$0(orcid)0000-0001-9359-0019$$aCalatayud, M.P. 000075865 700__ $$0(orcid)0000-0003-1558-9279$$aGoya, G.F.$$uUniversidad de Zaragoza 000075865 700__ $$aCuschieri, A. 000075865 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada 000075865 773__ $$g115 (2018), [8 pp]$$pBiophys. j.$$tBIOPHYSICAL JOURNAL$$x0006-3495 000075865 8564_ $$s237311$$uhttps://zaguan.unizar.es/record/75865/files/texto_completo.pdf$$yVersión publicada 000075865 8564_ $$s117958$$uhttps://zaguan.unizar.es/record/75865/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000075865 909CO $$ooai:zaguan.unizar.es:75865$$particulos$$pdriver 000075865 951__ $$a2020-01-17-21:23:43 000075865 980__ $$aARTICLE